DrRoberta Magliozzi

Since when I started to work in 2000 my main research interest was neuroimmunology and neuropathology to better understand the immunopathological mechanisms involved in chronic inflammation and in particular in multiple sclerosis (MS). From 2004, when I started the PhD at Imperial College London under the supervision of Prof. R. Reynolds, I have paid particular attention to the inflammatory response and the role of ectopic lymphoid-like structures in the meningeal intrathecal inflammation and the association with cortical grey matter pathology and more severe disease outcome. In addition, in collaboration with clinical groups at Imperial College and University of Verona (Italy), I have also focused to translate neuroimmunological and neuropathological findings in potential new MS biomarkers of the different disease phenotypes and of MS progression.
The aim for my future research is to investigate the detailed molecular mechanisms involved in compartmentalised inflammation and subsequent neurodegeneration in the MS brain. This will involve a focus on the use of a multi-omics approach on well characterised human brain tissue samples and validation with cell and animal systems, with the ultimate aim of identifying novel therapeutic approaches to treat progressive MS. This will also help to involve young students and researches in neuroimmunology/neuropathology studies of chronic-inflammatory diseases.