DrNicholas Crump

My background is as a chromatin biologist, and I’m interested in understanding the mechanisms that control gene expression, focussing on how they are dysregulated in multiple myeloma. I hold a Kay Kendall Leukaemia Fund Intermediate Fellowship, through which I am exploring the role of spontaneous chromatin changes in the evolution of drug resistance in multiple myeloma. My fellowship is focussed on exploring the epigenetic changes that happen during relapse to understand how drug resistance can arise without requiring genetic mutations – and finding therapeutic targets to reverse this.