ProfessorChristian Speck
Professor of Genome Biochemistry & Molecular Biology
Institute of Clinical Sciences - Faculty of Medicine
Orcid identifier0000-0001-6646-1692 (opens in a new tab)
- Professor of Genome Biochemistry & Molecular BiologyInstitute of Clinical Sciences - Faculty of Medicine
- 07961 815 557 (Work)
- 2.14B, LMS Building, Hammersmith Campus, United Kingdom
BIO
SPECK LAB OVERVIEW
The group's objective is to discover new mechanisms in initiation of DNA replication and to understand the function of replication factors in hetero-chromatin formation and epigenetic memory. This knowledge is used to understand disease-associated processes and to develop novel DNA replication inhibitors. We employ truly interdisciplinary approaches, including biochemistry, genome-wide AlphaFold screens, cryo-EM, high-resolution genomics, chemical biology, genetics and molecular dynamics simulations to understand biological processes holistically.
We collaborate with ICL Chemistry (Anna Barnard, ICL White City Campus) and MRC-LMS (Alexis Barr, Hammersmith Campus) to exploit our biological insights for inhibitor development. Together with DeepChain we use molecular dynamics simulations and AI-driven analysis of protein sequences to understand the function of multi-protein complexes.
Enquiries from motivated and exceptional students and postdocs about working in the group are always welcome. Please send a full CV and cover letter to chris.speck@imperial.ac.uk
The group's objective is to discover new mechanisms in initiation of DNA replication and to understand the function of replication factors in hetero-chromatin formation and epigenetic memory. This knowledge is used to understand disease-associated processes and to develop novel DNA replication inhibitors. We employ truly interdisciplinary approaches, including biochemistry, genome-wide AlphaFold screens, cryo-EM, high-resolution genomics, chemical biology, genetics and molecular dynamics simulations to understand biological processes holistically.
We collaborate with ICL Chemistry (Anna Barnard, ICL White City Campus) and MRC-LMS (Alexis Barr, Hammersmith Campus) to exploit our biological insights for inhibitor development. Together with DeepChain we use molecular dynamics simulations and AI-driven analysis of protein sequences to understand the function of multi-protein complexes.
Enquiries from motivated and exceptional students and postdocs about working in the group are always welcome. Please send a full CV and cover letter to chris.speck@imperial.ac.uk
ACADEMIC POSITIONS
- ProfessorImperial College London, Institute of Clinical Sciences, United Kingdom1 Sep 2016 - present
FACULTY
- Faculty of Medicine
POSITION NAME
- Professor of Genome Biochemistry & Molecular Biolo