ProfessorChristian Speck
Professor of Genome Biochemistry & Molecular Biology
Institute of Clinical Sciences - Faculty of Medicine
Orcid identifier0000-0001-6646-1692 (opens in a new tab)
- Professor of Genome Biochemistry & Molecular BiologyInstitute of Clinical Sciences - Faculty of Medicine
- 07961 815 557 (Work)
- 2.14B, LMS Building, Hammersmith Campus, United Kingdom
RESEARCH
Overview
Our group studies mechanisms in genome stability and epigenetics using biochemical, high-resolution genomics, single-molecule and structural approaches. We are particularly interested in diseases associated with these processes and the development of specific inhibitors for therapeutic purposes.
The current work of the Group focuses on these projects:
- High-resolution genomic analysis of helicase loading to uncover how replication origins are recognised, regulated and function for genome stability
- Discovering the structural and mechanistic principles of human helicase-loading control and its misregulation in cancer
- The role of human helicase loading factors in epigenetic memory
- Structural and functional analysis of helicase activation mechanisms in budding yeast
- Discovery of fundamental mechanisms in the loading of the replicative DNA helicase in budding yeast
For details, please see the group website: https://www.specklab.com/
Our group studies mechanisms in genome stability and epigenetics using biochemical, high-resolution genomics, single-molecule and structural approaches. We are particularly interested in diseases associated with these processes and the development of specific inhibitors for therapeutic purposes.
The current work of the Group focuses on these projects:
- High-resolution genomic analysis of helicase loading to uncover how replication origins are recognised, regulated and function for genome stability
- Discovering the structural and mechanistic principles of human helicase-loading control and its misregulation in cancer
- The role of human helicase loading factors in epigenetic memory
- Structural and functional analysis of helicase activation mechanisms in budding yeast
- Discovery of fundamental mechanisms in the loading of the replicative DNA helicase in budding yeast
For details, please see the group website: https://www.specklab.com/
GRANTS
- GRANTA modern cryo-EM instrument for biological samples at Imperial College LondonWellcome Trust21 Sep 2020 - 20 Sep 2025
- EQUIPMENTA proteomics platform to enable next generation multidisciplinary bioscienceBiotechnology and Biological Sciences Research Cou