DrTony Goldstone
Clinical Associate Professor in PsychoNeuroEndocrinology
Department of Brain Sciences - Faculty of Medicine
Orcid identifier0000-0001-8179-7071 (opens in a new tab)
- Clinical Associate Professor in PsychoNeuroEndocrinologyDepartment of Brain Sciences - Faculty of Medicine
- 020 7594 5989 (Work)
- Imperial College London, Room S25B, 2nd Floor Commonwealth Building, Dept of. Brain Sciences, Hammersmith Hospital, Du Cane Road, London, W12 0NN, United Kingdom
RESEARCH
Grants
Selected Research Grants:
2006 Wellcome Trust Value in People Award: "Using functional neuroimaging to identify hormone and brain appetite pathways and their defects in obesity", PI
2007 Hammersmith Hospitals Trustees' Research Committee: "How does ghrelin increase appetite in the brain: a functional magnetic resonance imaging study?", PI
2008 Hammersmith Hospitals Trustees' Research Committee: "How does hunger alter brain activity at rest?", PI
2010-2012 Pfizer: "Growth hormone and traumatic brain injury: a neuroimaging study", Co-PI with Dr David Sharp, Consultant Neurologist, Imperial College London
2010 Imperial College Healthcare Charity: "How do changes in gut hormones after obesity surgery reduce appetite in the brain?", PI
2010-2011 NIHR CLRN award: Research nurse for NIHR CRN Portfolio studies in obesity imaging in CPG6, Imperial College Healthcare NHS Trust, PI
2010-2014 Core MRC funding, Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Co-Investigator, with PI Prof. Jimmy Bell
2011-2012 GW Pharma: "Pilot, dose-ranging study to assess the effect of cannabidiol (CBD) on liver fat levels in subjects with fatty liver disease", PI
2013-2017 NIHR/MRC Efficacy and Mechanism Evaluation Programme: "A randomized controlled trial of a duodenal sleeve bypass device (Endobarrier) compared with standard medical therapy for the management of obese subjects with type II diabetes", includes functional MRI scans for mechanistic studies, Co-Investigator with PI Dr Julian Teare
2014-2018 MRC Experimental Medicine Challenge Grant MR/M007022/1: "Do appetitive gut hormones attenuate core behavioural components of addiction as new targets to prevent relapse in nicotine and alcohol dependence?", Co-PI
2015-2021 MRC: "The MRC Addiction Research Clinical (MARC) Training programme", Co-Investigator with PI Prof. Anne Lingford-Hughes
2019-2020 Division of Medicine and Integrated Care, Imperial College Healthcare NHS Trust: “Gut Hormones in Addiction (GHADD) Study: targeting GLP-1 and ghrelin pathways to treat nicotine and alcohol dependence, and obesity”, PI
2021-2023 Ministerio de Ciencia, Innovacion y Universidades, Spain: “Neural food reward mechanisms for weight regain and successful maintenance of weight loss after sleeve gastrectomy. A multimodal study with functional magnetic resonance”, Co-Inv (PI, Lilliam Flores)
2021-2024 MRC Population and Systems Medicine Board Research Grant MR/T017279/1: “Human experimental medicine studies of gut hormone LEAP2, an endogenous ghrelin antagonist and target for obesity, diabetes, cachexia and addiction”, PI
2020-2021 NIHR NW London CRN award (£11,233): Research nurse support for NIHR CRN Portfolio studies in obesity, Imperial College Healthcare NHS Trust, Co-PI with Alexander Miras
2022-2025 NIHR NW London CRN award: Research nurse support for NIHR CRN Portfolio studies in obesity, Imperial College Healthcare NHS Trust, Co-PI with Alexander Miras
2024-2025 RIPEN Innovation Hub (TRanslational Innovation Hub for Population HEalth using Food and Nutrition approaches to enhance Positive Physiology) - Progression Award, Biotechnology and Biological Sciences Research Council (BBSRC) Diet and Health Open Innovation Research Club: “Identifying mediators of satiety in humans”, PI
Student grants (Principal Supervisor and Investigator)
2009-2013 Wellcome Trust Research Training Fellowship Samantha Scholtz: "Functional magnetic resonance imaging of appetite and eating behaviour in obesity surgery"
2009-2010 Imperial College Healthcare Charity Clinical Research Fellowship Navpreet Chhina: "How does obesity surgery reduce appetite in the brain: a functional magnetic resonance imaging study?
2010-2013 MRC Clinical Training Fellowship Alex Miras: "Altered reward responses to sweet taste: a potential mechanism for weight loss after obesity surgery"
2011-2012 Imperial College Healthcare Charity Research Fellowship Carmen Tenorio Jiménez: "What is the impact of early growth hormone deficiency on brain function after traumatic brain injury?"
2011-2012 Imperial College Healthcare Charity Research Fellowship: "How do obesity and variations in obesity-associated genes influence eating behaviour: structural and functional MRI brain studies?"
2013-2016 MRC Clinical Training Fellowship Claire Feeney: "Does the metabolic syndrome impair recovery from traumatic brain injury: a prospective neuroimaging and cognitive study?", Co-PI with David Sharp
2013-2016 Wellcome Trust - GlaxoSmithKline Translational Medicine Training Fellowship, Imperial College London Navpreet Chhina: "Multi-modal phenotyping and network analysis of eating and addictive behaviours after bariatric interventions for obesity and diabetes mellitus"
2019-2021 Imperial Post-Doctoral, Post-CCT Research Fellowship, Imperial College London, Eleanor Sandhu: “Exploring the effect of renal haemodialysis and the gut hormone uroguanylin on salt appetite” (Co-supervisor)
2018-2025 Saudi Arabia Government PhD Scholarship, Ghadah Aldubaikhi: “Eating behaviour and metabolomics in obesity and its treatment”
2024-2028 Indonesia Endowment Fund for Education (LPDP PTUD) PhD Scholarship, Tasya Parastika: “Influence of gut hormone LEAP2 on eating and addictive behaviours in humans”
Selected Research Grants:
2006 Wellcome Trust Value in People Award: "Using functional neuroimaging to identify hormone and brain appetite pathways and their defects in obesity", PI
2007 Hammersmith Hospitals Trustees' Research Committee: "How does ghrelin increase appetite in the brain: a functional magnetic resonance imaging study?", PI
2008 Hammersmith Hospitals Trustees' Research Committee: "How does hunger alter brain activity at rest?", PI
2010-2012 Pfizer: "Growth hormone and traumatic brain injury: a neuroimaging study", Co-PI with Dr David Sharp, Consultant Neurologist, Imperial College London
2010 Imperial College Healthcare Charity: "How do changes in gut hormones after obesity surgery reduce appetite in the brain?", PI
2010-2011 NIHR CLRN award: Research nurse for NIHR CRN Portfolio studies in obesity imaging in CPG6, Imperial College Healthcare NHS Trust, PI
2010-2014 Core MRC funding, Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Co-Investigator, with PI Prof. Jimmy Bell
2011-2012 GW Pharma: "Pilot, dose-ranging study to assess the effect of cannabidiol (CBD) on liver fat levels in subjects with fatty liver disease", PI
2013-2017 NIHR/MRC Efficacy and Mechanism Evaluation Programme: "A randomized controlled trial of a duodenal sleeve bypass device (Endobarrier) compared with standard medical therapy for the management of obese subjects with type II diabetes", includes functional MRI scans for mechanistic studies, Co-Investigator with PI Dr Julian Teare
2014-2018 MRC Experimental Medicine Challenge Grant MR/M007022/1: "Do appetitive gut hormones attenuate core behavioural components of addiction as new targets to prevent relapse in nicotine and alcohol dependence?", Co-PI
2015-2021 MRC: "The MRC Addiction Research Clinical (MARC) Training programme", Co-Investigator with PI Prof. Anne Lingford-Hughes
2019-2020 Division of Medicine and Integrated Care, Imperial College Healthcare NHS Trust: “Gut Hormones in Addiction (GHADD) Study: targeting GLP-1 and ghrelin pathways to treat nicotine and alcohol dependence, and obesity”, PI
2021-2023 Ministerio de Ciencia, Innovacion y Universidades, Spain: “Neural food reward mechanisms for weight regain and successful maintenance of weight loss after sleeve gastrectomy. A multimodal study with functional magnetic resonance”, Co-Inv (PI, Lilliam Flores)
2021-2024 MRC Population and Systems Medicine Board Research Grant MR/T017279/1: “Human experimental medicine studies of gut hormone LEAP2, an endogenous ghrelin antagonist and target for obesity, diabetes, cachexia and addiction”, PI
2020-2021 NIHR NW London CRN award (£11,233): Research nurse support for NIHR CRN Portfolio studies in obesity, Imperial College Healthcare NHS Trust, Co-PI with Alexander Miras
2022-2025 NIHR NW London CRN award: Research nurse support for NIHR CRN Portfolio studies in obesity, Imperial College Healthcare NHS Trust, Co-PI with Alexander Miras
2024-2025 RIPEN Innovation Hub (TRanslational Innovation Hub for Population HEalth using Food and Nutrition approaches to enhance Positive Physiology) - Progression Award, Biotechnology and Biological Sciences Research Council (BBSRC) Diet and Health Open Innovation Research Club: “Identifying mediators of satiety in humans”, PI
Student grants (Principal Supervisor and Investigator)
2009-2013 Wellcome Trust Research Training Fellowship Samantha Scholtz: "Functional magnetic resonance imaging of appetite and eating behaviour in obesity surgery"
2009-2010 Imperial College Healthcare Charity Clinical Research Fellowship Navpreet Chhina: "How does obesity surgery reduce appetite in the brain: a functional magnetic resonance imaging study?
2010-2013 MRC Clinical Training Fellowship Alex Miras: "Altered reward responses to sweet taste: a potential mechanism for weight loss after obesity surgery"
2011-2012 Imperial College Healthcare Charity Research Fellowship Carmen Tenorio Jiménez: "What is the impact of early growth hormone deficiency on brain function after traumatic brain injury?"
2011-2012 Imperial College Healthcare Charity Research Fellowship: "How do obesity and variations in obesity-associated genes influence eating behaviour: structural and functional MRI brain studies?"
2013-2016 MRC Clinical Training Fellowship Claire Feeney: "Does the metabolic syndrome impair recovery from traumatic brain injury: a prospective neuroimaging and cognitive study?", Co-PI with David Sharp
2013-2016 Wellcome Trust - GlaxoSmithKline Translational Medicine Training Fellowship, Imperial College London Navpreet Chhina: "Multi-modal phenotyping and network analysis of eating and addictive behaviours after bariatric interventions for obesity and diabetes mellitus"
2019-2021 Imperial Post-Doctoral, Post-CCT Research Fellowship, Imperial College London, Eleanor Sandhu: “Exploring the effect of renal haemodialysis and the gut hormone uroguanylin on salt appetite” (Co-supervisor)
2018-2025 Saudi Arabia Government PhD Scholarship, Ghadah Aldubaikhi: “Eating behaviour and metabolomics in obesity and its treatment”
2024-2028 Indonesia Endowment Fund for Education (LPDP PTUD) PhD Scholarship, Tasya Parastika: “Influence of gut hormone LEAP2 on eating and addictive behaviours in humans”