DrTony Nolan
Honorary Senior Lecturer
Department of Life Sciences - Faculty of Natural Sciences
Orcid identifier0000-0002-2982-8333 (opens in a new tab)
- Honorary Senior LecturerDepartment of Life Sciences - Faculty of Natural Sciences
- Sir Alexander Fleming Building, South Kensington Campus, United Kingdom
RESEARCH
AREAS OF INTEREST
Oogenesis in the mosquito
Chorion formation in the mosquito egg
Sex determination mechanisms in the mosquito
Gene drive to modify insect vector populations
Sex chromosome biology in mosquitoes
The role of non-coding RNAs in the mosquito germline
CRISPR as a genome editing tool in the mosquito
Experimental evolution in the mosquito to rapidly select traits
The genetics of insecticide resistance
Developing new functional genetics tool for different mosquito species
RELEVANT PUBLICATIONS
A Beaghton, A Hammond, T Nolan, A Crisanti, HCJ Godfray, A Burt. Requirements for Driving Antipathogen Effector Genes into Populations of Disease Vectors by Homing. Genetics 2017, 205 (4), 1587-1596
AB Hall, PA Papathanos, A Sharma, C Cheng, OS Akbari, L Assour, ...T Nolan… IV Sharakhov, ZJ Tu, NJ Besansky Radical remodeling of the Y chromosome in a recent radiation of malaria mosquitoes PNAS 2016, 201525164
Roberto Galizi, Andrew Hammond, Kyros Kyrou, Chrysanthi Taxiarchi, Federica Bernardini, Samantha M O’Loughlin, Philippos-Aris Papathanos, Tony Nolan, Nikolai Windbichler, Andrea Crisanti A CRISPR-Cas9 sex-ratio distortion system for genetic control Scientific Reports 2016 Vol 6
Hammond A, Galizi R, Kyrou K, Simoni A, Siniscalchi C, Katsanos D, Gribble M, Baker D, Marois E, Russell S, Burt A, Windbichler N, Crisanti A, Nolan T. A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae. Nature Biotechnology 2016, 34, 78–83
L Castellano, E Rizzi, J Krell, M Di Cristina, R Galizi, A Mori, J Tam, G DeBellis, J Stebbing, A Crisanti, T Nolan.The germline of the malaria mosquito produces abundant miRNAs, endo-siRNAs, piRNAs and 29-nt small RNAs BMC genomics 2015 Feb 19 16 (1), 100
DE Neafsey, RM Waterhouse, MR Abai, SS Aganezov, MA Alekseyev et al. Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes Science 2015 Jan 2 347 (6217), 1258522
G Volohonsky, O Terenzi, J Soichot, DA Naujoks, T Nolan…S Blandin, E Marois. Tools for Anopheles gambiae transgenesis G3: Genes| Genomes| Genetics 5 (6), 1151-1163
S Fuchs, E Rende, A Crisanti, T Nolan. Disruption of aminergic signalling reveals novel compounds with distinct inhibitory effects on mosquito reproduction, locomotor function and survival Scientific Reports Jul 2;4:5526
SB Thyme, SJS Boissel, SA Quadri, T Nolan, D Baker et al... Reprogramming homing endonuclease specificity through computational design and directed evolution Nucleic Acids Research 2014 42 (4), 2564-2576
Baker DA, Nolan T, Fischer B, Pinder A, Crisanti A, Russell S. A comprehensive gene expression atlas of sex- and tissue-specificity in the malaria vector, Anopheles gambiae. BMC Genomics. 2011 Jun 7;12:296.
Nolan T, Papathanos P, Windbichler N, Magnusson K, Benton J, Catteruccia F, Crisanti A. Developing transgenic Anopheles mosquitoes for the sterile insect technique. Genetica. 2011 Jan;139(1):33-9.
T Nolan, G Cecere, C Mancone, T Alonzi, M Tripodi, C Catalanotto C cogoni The RNA-dependent RNA polymerase essential for post-transcriptional gene silencing in Neurospora crassa interacts with replication protein A Nucleic Acids Research 2008, 36 (2), 532-538
Nolan T, Braccini L, Azzalin, De Toni A, Macino G, Cogoni C. The post-transcriptional gene silencing machinery functions independently of DNA methylation to repress a LINE1-like retrotransposon in Neurospora crassa. Nucleic Acids Research 2005 Mar 14;33(5):1564-73
Catteruccia F*, Nolan T*, Loukeris TG, Blass C, Savakis C, Kafatos FC, Crisanti A. Stable germline transformation of the malaria mosquito Anopheles stephensi. Nature. 2000 Jun 22;405(6789):959-62. (* joint first authors)
Oogenesis in the mosquito
Chorion formation in the mosquito egg
Sex determination mechanisms in the mosquito
Gene drive to modify insect vector populations
Sex chromosome biology in mosquitoes
The role of non-coding RNAs in the mosquito germline
CRISPR as a genome editing tool in the mosquito
Experimental evolution in the mosquito to rapidly select traits
The genetics of insecticide resistance
Developing new functional genetics tool for different mosquito species
RELEVANT PUBLICATIONS
A Beaghton, A Hammond, T Nolan, A Crisanti, HCJ Godfray, A Burt. Requirements for Driving Antipathogen Effector Genes into Populations of Disease Vectors by Homing. Genetics 2017, 205 (4), 1587-1596
AB Hall, PA Papathanos, A Sharma, C Cheng, OS Akbari, L Assour, ...T Nolan… IV Sharakhov, ZJ Tu, NJ Besansky Radical remodeling of the Y chromosome in a recent radiation of malaria mosquitoes PNAS 2016, 201525164
Roberto Galizi, Andrew Hammond, Kyros Kyrou, Chrysanthi Taxiarchi, Federica Bernardini, Samantha M O’Loughlin, Philippos-Aris Papathanos, Tony Nolan, Nikolai Windbichler, Andrea Crisanti A CRISPR-Cas9 sex-ratio distortion system for genetic control Scientific Reports 2016 Vol 6
Hammond A, Galizi R, Kyrou K, Simoni A, Siniscalchi C, Katsanos D, Gribble M, Baker D, Marois E, Russell S, Burt A, Windbichler N, Crisanti A, Nolan T. A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae. Nature Biotechnology 2016, 34, 78–83
L Castellano, E Rizzi, J Krell, M Di Cristina, R Galizi, A Mori, J Tam, G DeBellis, J Stebbing, A Crisanti, T Nolan.The germline of the malaria mosquito produces abundant miRNAs, endo-siRNAs, piRNAs and 29-nt small RNAs BMC genomics 2015 Feb 19 16 (1), 100
DE Neafsey, RM Waterhouse, MR Abai, SS Aganezov, MA Alekseyev et al. Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes Science 2015 Jan 2 347 (6217), 1258522
G Volohonsky, O Terenzi, J Soichot, DA Naujoks, T Nolan…S Blandin, E Marois. Tools for Anopheles gambiae transgenesis G3: Genes| Genomes| Genetics 5 (6), 1151-1163
S Fuchs, E Rende, A Crisanti, T Nolan. Disruption of aminergic signalling reveals novel compounds with distinct inhibitory effects on mosquito reproduction, locomotor function and survival Scientific Reports Jul 2;4:5526
SB Thyme, SJS Boissel, SA Quadri, T Nolan, D Baker et al... Reprogramming homing endonuclease specificity through computational design and directed evolution Nucleic Acids Research 2014 42 (4), 2564-2576
Baker DA, Nolan T, Fischer B, Pinder A, Crisanti A, Russell S. A comprehensive gene expression atlas of sex- and tissue-specificity in the malaria vector, Anopheles gambiae. BMC Genomics. 2011 Jun 7;12:296.
Nolan T, Papathanos P, Windbichler N, Magnusson K, Benton J, Catteruccia F, Crisanti A. Developing transgenic Anopheles mosquitoes for the sterile insect technique. Genetica. 2011 Jan;139(1):33-9.
T Nolan, G Cecere, C Mancone, T Alonzi, M Tripodi, C Catalanotto C cogoni The RNA-dependent RNA polymerase essential for post-transcriptional gene silencing in Neurospora crassa interacts with replication protein A Nucleic Acids Research 2008, 36 (2), 532-538
Nolan T, Braccini L, Azzalin, De Toni A, Macino G, Cogoni C. The post-transcriptional gene silencing machinery functions independently of DNA methylation to repress a LINE1-like retrotransposon in Neurospora crassa. Nucleic Acids Research 2005 Mar 14;33(5):1564-73
Catteruccia F*, Nolan T*, Loukeris TG, Blass C, Savakis C, Kafatos FC, Crisanti A. Stable germline transformation of the malaria mosquito Anopheles stephensi. Nature. 2000 Jun 22;405(6789):959-62. (* joint first authors)