DrSonia Nielles-Vallespin
Associate Professor in Cardiac Magnetic Resonance Physics
National Heart & Lung Institute - Faculty of Medicine
Orcid identifier0000-0003-0412-2796 (opens in a new tab)
- Associate Professor in Cardiac Magnetic Resonance PhysicsNational Heart & Lung Institute - Faculty of Medicine
- Guy Scadding Building, Royal Brompton Campus, United Kingdom
RESEARCH
DIFFUSION TENSOR CARDIAC MAGNETIC RESONANCE
Cardiomyocytes are syncytially arranged in differing helically aligned orientations throughout the depth of the myocardial wall and organised into secondary structures called sheetlets.
In vivo diffusion tensor cardiac magnetic resonance (DT-CMR) enables non-invasive and non-destructive interrogation of this three-dimensional microstructural organization and its dynamics. DT-CMR quantifies water diffusion in the myocardium, which is constrained by the myocardial micro-architecture. Both in vivo and ex vivo DT-CMR techniques can provide invaluable information about the microstructure of healthy myocardium and the pathophysiological changes in disease.
Cardiomyocytes are syncytially arranged in differing helically aligned orientations throughout the depth of the myocardial wall and organised into secondary structures called sheetlets.
In vivo diffusion tensor cardiac magnetic resonance (DT-CMR) enables non-invasive and non-destructive interrogation of this three-dimensional microstructural organization and its dynamics. DT-CMR quantifies water diffusion in the myocardium, which is constrained by the myocardial micro-architecture. Both in vivo and ex vivo DT-CMR techniques can provide invaluable information about the microstructure of healthy myocardium and the pathophysiological changes in disease.
GRANTS
- STANDARD - CALLClinical Cardiovascular Magnetic Resonance in a third of the time through robust Simultaneous Multi-Slice Parallel Imaging TechnologyHeart Research UK1 Oct 2024 - 30 Sep 2027