I am a Consultant Respiratory Physician at the Royal Brompton and Harefield NHS Foundation Trust and Horonary Clinical Senior Lecturer at Imperial College London.

Following completion of my medical training at Imperial College London alongside an intercalated BSc, I trained as a respiratory doctor within North West London and spent time working within the lung transplant unit at Harefield Hospital and the Host Defence Unit at the Royal Brompton hospital. It was during this time that I encountered numerous individuals with fungal lung infection and developed my academic interest to try and better understand host susceptibility to fungal infection and develop translational research strategies to improve outcome.

This interest led to a MRC clinical PhD research fellowship in 2012-2015 in the Armstrong-James laboratory at Imperial College London analysing the effects of calcineurin inhibition on the human macrophage response to Aspergillus fumigatus using a combination of high-resolution time-lapse confocal microscopy alongside an 'omics' based approach. This work was published in the American Journal of Critical Care Medicine and presented at numerous national and international presentations.

Following completion of my PhD and clinical training, I took up a Consultant position at the Royal Brompton and Harefield NHS Foundation Trust in October 2016, working in the adult Cystic Fibrosis and Host Defence departments. I have continued and expanded my academic interests and research during this time, receiving numerous research awards and funding. My research focus areas primarily are within pulmonary fungal lung disease, bronchiectasis and antimicrobial resistance.

Awards:
Medical Research Foundation - Skills and development award 2022
MRC Clinical Academic Research Partnership award - 2019
CF Trust Venture Innovation award - 2019
Vertex Research Innovation award - 2018
Gilead Invasive Fungal Infection fellowship award - 2018
CF Trust Clinical Excellance and Innovation award - 2017
Darzi Fellowship in Clinical Leadership (Sponsor) - 2017 and 2018
MRC Clinical PhD Research Fellowship - 2012

CURRENT RESEARCH:
Bronchiectasis: I have a widening research interest in identifying novel models and potential therapeutic pathways in non-CF bronchiectasis with a number of ongoing funded studies as below:

- BARRIER study - human BronchiectAsis RhinoviRus challenge to define Immunopathogenesis of ExaceRbation - co-Chief Investigator of MRC experimental medicine programme grant developing the first human viral challenge model of bronchiectasis exacerbation. Co-PIs - Dr Aran Singanayagam, Prof Sebastian Johnston; co-Is - Prof James Chalmers, Prof Sanjay Chotirmal, Prof Tom Wilkinson

- PRIVILEGE study - PRospective cohort study to understand Impact of VIraL infEction in chronic lunG diseasE. Chief Investigator of cohort study to understand impact of viral infection in chronic lung disease exacerbations. co-PI - Dr Aran Singanayagam

- EMILE study - Evaluation of the effect of Microbial dysbiosis upon anti-viral Immunity in bronchiEctasis. co-PI of observational bronchoscopy study to analyse effects of microbial dysbiosis in bronchiectasis. co-PIs - Dr Aran Singanayagam, Dr Justin Garner.

Fungal research:
As co-director of the Imperial Fungal Disease Network of Excellence I have a number of ongoing research interested in fungal lung disease as below:

- CAPSULE study: Impact of Chronic Pulmonary Aspergillosis (CPA) on health status and Well-being. Chief Investigator of study to develop and validate a novel disease-specific health-related quality of life questionnaire in chronic pulmonary aspergillosis to better understand treatment endpoints. co-Is - Prof Darius Armstrong-James; Dr Melody Ni

- Fungal Resistance Evolution and Acquisition in chronic Lung disease (FREAL) study. Primary Investigator in MRC funded multicentre prospective longitudinal study using whole genome sequencing to understand fungal resistance evolution and acquisition in chronic lung disease. Collaborators - Professor Matthew Fisher, Dr Pantelis Georgiou, Dr Darius Armstrong-James, Imperial College London and Professor James Chalmers, University Of Dundee.

- TrIFIC: Targeting Immunotherapy for Fungal Infections in Cystic Fibrosis. Co-Investigator in CF Trust Strategic Research Centre grant to immunophenotype fungal disease in Cystic Fibrosis and assess targeted immunotherapeutics to improve outcome in CF fungal disease.

Antimicrobial resistance:
I co-chair the European Respiratory Society AMR-Lung clinical research collaboration with over 300 members globally and a number of ongoing research work packages and studies.