DrShuchi Agrawal Singh
Assistant Professor in Haematology
Department of Immunology and Inflammation - Faculty of Medicine
Orcid identifier0000-0001-8632-4556 (opens in a new tab)
- Assistant Professor in HaematologyDepartment of Immunology and Inflammation - Faculty of Medicine
- Imperial College London, Department of Immunology and Inflammation, 4N7A, Commonwealth Building, Hammersmith Campus,, Du Cane Road, London, United Kingdom
BIO
With a longstanding interest in epigenetics and chromatin biology, Dr. Shuchi Agrawal-Singh’s research focuses on understanding the molecular mechanisms underlying Acute Myeloid Leukemia (AML), an aggressive blood cancer originating from white blood cells of the myeloid lineage. AML is characterized by uncontrolled proliferation and blocked differentiation. Agrawal-Singh’s lab is interested in investigating how mutations in epigenetic modulators leads to dysregulated “epigenetic language” driving abnormal- gene transcription, chromatin organisation and impact biomolecular condensation in leukemogenesis, with the aim of implementing these discoveries for the development of novel epigenetic therapies.
Dr. Agrawal Singh received her PhD in Biology (Molecular Haematology/Oncology) from University of Muenster, Germany. Her work was amongst the earlier studies that defined the importance of DNA-promoter-hypermethylation in silencing tumour suppressor genes in acute myeloid leukaemia (AML) and to use it as potential MRD-biomarker for predicting relapse risk in AML patients. She received an outstanding PhD with 3 first author and 4 co-authored publications. Moving on with independent postdoctoral fellowship from Danish Research Council (FSS), she joined BRIC (Copenhagen University) for postdoctoral training. Her work at BRIC, demonstrated the dynamic role of Polycomb repressive complex (PRC2) in regulating the lineage specific enhancer and transcriptional control during human-mesenchymal stem-cells differentiation. Further her research continued at University of Cambridge, probing the molecular epigenetic mechanisms underlying AML pathogenesis and her work revealed a novel function of transcription factor HOXA9 as transcriptional repressor required to prevent differentiation in AML.
Since November 2024, Dr. Agrawal-Singh joined Imperial College London as non-clinical lecturer. She is the founder and co-organizer of the Cancer Chromatin & Epigenetics Club (CCEC), virtual monthly seminar series, run jointly with Imperial College and University of Cambridge. CCEC is globally leading online seminar series with 400-600 attendees each seminar, free educational and networking platform. https://www.haem.cam.ac.uk/events/cancer-chromatin-and-epigenetics-club
Dr. Agrawal Singh received her PhD in Biology (Molecular Haematology/Oncology) from University of Muenster, Germany. Her work was amongst the earlier studies that defined the importance of DNA-promoter-hypermethylation in silencing tumour suppressor genes in acute myeloid leukaemia (AML) and to use it as potential MRD-biomarker for predicting relapse risk in AML patients. She received an outstanding PhD with 3 first author and 4 co-authored publications. Moving on with independent postdoctoral fellowship from Danish Research Council (FSS), she joined BRIC (Copenhagen University) for postdoctoral training. Her work at BRIC, demonstrated the dynamic role of Polycomb repressive complex (PRC2) in regulating the lineage specific enhancer and transcriptional control during human-mesenchymal stem-cells differentiation. Further her research continued at University of Cambridge, probing the molecular epigenetic mechanisms underlying AML pathogenesis and her work revealed a novel function of transcription factor HOXA9 as transcriptional repressor required to prevent differentiation in AML.
Since November 2024, Dr. Agrawal-Singh joined Imperial College London as non-clinical lecturer. She is the founder and co-organizer of the Cancer Chromatin & Epigenetics Club (CCEC), virtual monthly seminar series, run jointly with Imperial College and University of Cambridge. CCEC is globally leading online seminar series with 400-600 attendees each seminar, free educational and networking platform. https://www.haem.cam.ac.uk/events/cancer-chromatin-and-epigenetics-club
ACADEMIC POSITIONS
- Non Clinical LecturerImperial College London, Department of Immunology and Inflammation, London, United Kingdom4 Nov 2024 - present
DEGREES
- PhDUniversity of Muenster, Muenster, Germany
FACULTY
- Faculty of Medicine
POSITION NAME
- Assistant Professor in Haematology