DrRanil De Silva

Dr Ranil de Silva is a Senior Lecturer in Clinical Cardiology and Consultant Interventional Cardiologist at the Royal Brompton Hospital, where he leads the Specialist Angina Service.

Education

Dr de Silva studied Medicine at King's College School of Medicine and Dentistry. He was awarded a First Class honours degree in Physiology after which he won a Medical Research Council PhD Studentship to continue research under the supervision of Professor Attilio Maseri, Professor Giovanni Mann and Professor Terry Jones at the MRC Cyclotron Unit, Hammersmith Hospital, in the field of cardiac positron emission tomography. He was awarded his PhD in 1993. He then returned to complete his undergraduate medical training and graduated with distinction in 1995.

Dr de Silva completed his training in general and interventional cardiology in London, including at the Royal Brompton, Hammersmith and St Mary's Hospitals. He undertook post-doctoral research at the Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, USA with Robert Lederman in the area of MRI guided endovascular intervention and biologic therapies for cardiovascular disease.

He was appointed to his current post in August 2007.

Research

Dr de Silva's research focuses on the use of imaging (invasive intracoronary and non-invasive cross-sectional) in the diagnosis and risk stratification and evaluation of treatment of coronary artery disease. He also has an interest in hypertension management.

His work is funded by the British Heart Foundation. He currently co-supervises 2 PhD and 1 Masters student.

Clinical Trials/Registries

Dr de Silva is UK or site PI for a number of multicentre clinical trials including BLADE (ClinicalTrials.gov identifier NCT02645799); EuroCTO (ClinicalTrials.gov identifier NCT01760083); Lipid Rich Plaque (ClinicalTrials.gov identifier NCT02033694); REDUCER-1 Registry; Ivabradine Drug Utilisation Study in Select European Countries: A Multinational, Retrospective, Observational Study to Assess Effectiveness of Risk-Minimisation Measures.

Current active areas of translational and clinical research

Shear stress and atherogenesis
Biomechanical models for the prediction of advanced coronary atherosclerotic plaque development and rupture risk.
Diffusion tensor cardiac magnetic resonance for prediction of adverse left ventricular remodelling, heart failure and arrhythmic risk after myocardial infarction
Diagnosis and treatment of microvascular dysfunction.
Novel approaches to management of patients with refractory angina
New approaches to the treatment of hypertension (renal denervation, ROX)
Professional Positions

Associate Board Member, NIHR-MRC Efficacy and Mechanism Evaluation Board (2007-2011)

Clinical Lead, Specialist Angina Service, Royal Brompton Hospital (2013-present)

Academic Lead, Coronary Disease Theme, Cardiovascular Research Unit, Royal Brompton Hospital (2016-present)

Member, British Cardiovascular Society Atherothrombosis Clinical Study Group (2016 - present)



Prizes and Awards

Medical Research Council PhD Studentship (1989-1992)

Winner - Japanese College of Cardiology, Young Investigator Competition (1993)

National Institute of Health, Bench to Bedside Award (2005-2008)

Medical Futures Cardiovascular Innovation Award (2008), co-recipient

Orloff Award, NHLBI Division of Intramural Research (2017), co-recipient



Teaching

Dr de Silva is involved in teaching of undergraduate medical students at Imperial.

He is involved in postgraduate teaching trainees in the London Deanery and is Educational Supervisor for trainees at the Royal Brompton Hospital.

He is the Module Lead for Coronary Disease in the MSc/PGCert in Innovations in Cardiovascular Science at NHLI.