DrMassimo Marenzana
Senior MRI Research Radiographer
Institute of Clinical Sciences - Faculty of Medicine
- Senior MRI Research RadiographerInstitute of Clinical Sciences - Faculty of Medicine
- 020 7594 5311 (Work)
- 4.32, Royal School of Mines, South Kensington Campus, United Kingdom
BIO
Dr Marenzana''s research is concerned with the basic biological mechanisms by which connective and skeletal tissue cells respond to the mechanical environment by remodelling the structure and composition of their extracellular matrix and how these built-in, evolutionary mechanisms are affected by pathological conditions.
Over the years his approach has been to combined quantitative imaging techniques with bespoke mechanotronic devices to accurately characterize the mechanical environment in which the mechanisms of cell-driven tissue remodelling were investigated. Using similar approaches, his group is now carrying out studies on the mechanobiology of the articular joints in mouse models of osteoarthritis. Their goal is to characterise the mechanical factors and the structural changes in articular cartilage and subchondral bone in mouse models of mechanically-induced osteoarthritis as the basis to pin down the relationship between mechanical stresses and the molecular signalling leading to joint pathology (see research pages).
After completing his PhD in 2004 at the Tissue Repair and Engineering Centre, University College London, Dr Marenzana held two postdoctoral positions in two bone research groups (Bone Metabolic Unit, San Raffaele Scientific Institute, Milano, Italy and Bone Group, Royal Veterinary College, London). In 2008 he was appointed senior research scientist in the R&D department of a pharmaceutical company based in UK, with the role of developing studies focussed on the biology of on sclerostin, a novel mechanotransduction-related bone pharmacological target (see CV for more details). Since 2010, he returned to academia, joining the Imperial College London with a lecturer appointment, joint between the Department of Bioengineering and the Kennedy Institute of Rheumatology Division. With this appointment, he has also joined the Centre for Medical Solutions in the Management of Osteoarthritis.
Dr Marenzana's research publications can be found at the tab above, or on Google Scholar.
Over the years his approach has been to combined quantitative imaging techniques with bespoke mechanotronic devices to accurately characterize the mechanical environment in which the mechanisms of cell-driven tissue remodelling were investigated. Using similar approaches, his group is now carrying out studies on the mechanobiology of the articular joints in mouse models of osteoarthritis. Their goal is to characterise the mechanical factors and the structural changes in articular cartilage and subchondral bone in mouse models of mechanically-induced osteoarthritis as the basis to pin down the relationship between mechanical stresses and the molecular signalling leading to joint pathology (see research pages).
After completing his PhD in 2004 at the Tissue Repair and Engineering Centre, University College London, Dr Marenzana held two postdoctoral positions in two bone research groups (Bone Metabolic Unit, San Raffaele Scientific Institute, Milano, Italy and Bone Group, Royal Veterinary College, London). In 2008 he was appointed senior research scientist in the R&D department of a pharmaceutical company based in UK, with the role of developing studies focussed on the biology of on sclerostin, a novel mechanotransduction-related bone pharmacological target (see CV for more details). Since 2010, he returned to academia, joining the Imperial College London with a lecturer appointment, joint between the Department of Bioengineering and the Kennedy Institute of Rheumatology Division. With this appointment, he has also joined the Centre for Medical Solutions in the Management of Osteoarthritis.
Dr Marenzana's research publications can be found at the tab above, or on Google Scholar.
FACULTY
- Faculty of Medicine
POSITION NAME
- Senior MRI Research Radiographer