DrMaria Elisa Lopes Pires
Teaching Fellow in Biomedical Science (Non-Clinical)
Faculty of Medicine Centre - Faculty of Medicine
- Teaching Fellow in Biomedical Science (Non-Clinical)Faculty of Medicine Centre - Faculty of Medicine
- Sir Alexander Fleming Building, South Kensington Campus, United Kingdom
BIO
Dr Lopes Pires is Teaching Fellow in the Faculty of Medicine. Her learning and teaching reflexions and her experience as a teacher in Brazil, have been recognised by the award of an Associate Fellowship of Higher Education (AFHEA) by the Higher Education Academy in 2020. She finalized her Postgraduate Teaching Certification (PGCert) and Diploma (PGDip). She is also a personal tutor of students, supporting them through their BMB course journey.
Research journey
Dr Lopes Pires is a cardiovascular pharmacologist who took part of Prof Jane Mitchell's and Dr Nicholas Kirkby's group at Vascular Biology section of the National Heart & Lung Institute. Her position was funded by British Heart Foundation Programme Grant. She worked with in vivo and ex vivo models of cardiovascular disease, seeking to understand the function of COX2 in the protection of cardiovascular system.
Dr Lopes Pires graduated in Biochemistry Pharmacy at UNESP (State University Julio de Mesquita Filho)- Brazil. In 2013, Dr Lopes Pires completed her PhD in Pharmacology at UNICAMP (State University of Campinas)- Brazil with Prof Sisi Marcondes, studying platelet reactivity and reactive oxygen species in sepsis condition (animal model). During this time, she did her doctoral internship at Université Jean Monnet- GIMAP- Pathophysiology and Prevention of infectious diseases- Santa Etienne-France, under supervision of Dr Fabrice Cognasse. She completed her first post-doctoral training under the guidance of Prof Jon Gibbins, at Reading University, where she worked with lipopolysaccharide effects in human platelet function. Before joining Imperial College, she worked at Anglia Ruskin University under the supervision of Dr Nick Pugh, completing a post-doctoral study about the function of zinc in human platelet reactivity.
Selected Publications
Clotting dysfunction in sepsis: a role for ROS and potential for therapeutic intervention. Lopes-Pires ME, Frade-Guanaes JO, Quinlan GJ. Antioxidants. 2022. Jan. doi: 10.3390/antiox11010088.
Endothelial cyclooxygenase-1 paradoxically drives local vasoconstriction and atherogenesis despite underpinning prostacyclin generation. Mitchell JA, Shala F, Pires MEL, Loy RY, Ravendren A, Benson J, Urquhart P, Nicolaou A, Herschman HR, Kirkby NS.Sci Adv. 2021 Mar 19;7(12):eabf6054. doi: 10.1126/sciadv.abf6054
Cyclooxygenases and the cardiovascular system Mitchell JA, Kirkby NS, Ahmetaj-Shala B, Armstrong PC, Crescente M, Ferreira P, Lopes Pires ME, Vaja R, Warner TD. Pharmacol Ther. 2021 Jan;217:107624. doi: 10.1016/j.pharmthera.2020.107624
Mitchell JA, Kirkby NS, Ahmetaj-Shala B, Armstrong PC, Crescente M, Ferreira P, Lopes Pires ME, Vaja R, Warner TD. Cyclooxygenases and the cardiovascular system. Pharmacol Ther. 2021 Jan;217:107624. doi: 10.1016/j.pharmthera.2020.107624
Agonist-Evoked Increases in Intra-Platelet Zinc Couple to Functional Responses. Ahmed NS, Lopes Pires ME, Taylor KA, Pugh N. Thrombosis and Haemost. 2019 Jan;119(1):128-139. doi: 10.1055/s-0038-1676589.
Lopes-Pires ME, Ahmed NS, Vara D, Gibbins JM, Pula G, Pugh N. Zinc regulates reactive oxygen species generation in platelets. Platelets. 2021 Apr 3;32(3):368-377. doi: 10.1080/09537104.2020.1742311
Signaling pathways involved in p47phox-dependent reactive-1 oxygen species in platelets of endotoxemic rats. Lopes Pires ME, Antunes AC, Antunes E, Garraud O, Cognasse F, Anhe GF, Marcondes S. Basic and Clinical Pharmacology and Toxicology. 2018 Oct 14. doi: 10.1111/bcpt.13148.
Tumor necrosis factor alpha has a crucial role on increased reactive oxygen species production in platelets of mice injected with lipopolysaccharide. Antunes AC, Bonfitto PH, Solon C, Lopes Pires ME, Anhe GF, Antunes E, Marcondes S. Platelets. 2018. (approved; waiting journal publication).
Stapled peptides as a new technology to investigate protein-protein interactions in human platelets. Jessica iegre, Niaz S Ahmed, Josephine S Gaynord, Yuteng Wu, Kara M Herlihy, Yaw Sing Tan, Maria E Lopes-Pires, Rupam Jha, Yu Heng Lau, Hannah Sore, Chandra Verma, Daniel H O'Donovan, Nicholas Pugh and David R Spring. Chemical Science. 2018 Apr 25;9(20):4638-4643. doi: 10.1039/C8SC00284C.
Sepsis: the involvement of platelets and the current treatments. Antunes AC, Guanaes JFO, Lopes Pires ME. Current Molecular Pharmacology. 2018 11(4):261-269. doi: 10.2174/187446721166618061912453
Platelet activity is negatively modulated by tumor necrosis factor alpha through reductions of cytosolic calcium levels and integrin alphaIIbbeta3 phosphorylation. Bonfitto PHL, Naime ACA, Lopes-Pires ME, Goulart G, Mendes-Silverio CB, Bueno PI, Castilho RF, Antunes E, Marcondes S. Thromb Res. 2018 Dec;172:44-5. doi: 10.1016/j.thromres.2018.10.008
Lipopolysaccharide potentiates platelet responses via toll-like receptor 4-stimulated Akt-Erk-PLA2 signalling. Lopes Pires ME, Clarke SR, Marcondes S, Gibbins JM. PLoS One. 2017 Nov 14;12(11):e0186981. doi: 10.1371/journal.pone.0186981.
Synthesis, antiplatelet and antithrombotic activities of resveratrol derivatives with NO-donor properties. Dutra LA, Guanaes JFO, Johmann N, Lopes Pires ME, Chin CM, Marcondes S, Dos Santos JL. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2450-2453. doi: 10.1016/j.bmcl.2017.04.007.
Cross-talking between lymphocytes and platelets and its regulation by nitric oxide and peroxynitrite in physiological condition and endotoxemia. Nádia J. Almeida Cardelli, M. Elisa Lopes-Pires, Pedro H. L. Bonfitto, Heloisa H. Ferreira, Edson Antunes, Sisi Marcondes. Life Sci. 2016 Dec 22. pii: S0024-3205(16)30708-1. doi: 10.1016/j.lfs.2016.12.013.
PKC and AKT Modulate cGMP/PKG Signaling Pathway on Platelet Aggregation in Experimental Sepsis. Lopes-Pires ME, Naime AC, Almeida Cardelli NJ, Anjos DJ, Antunes E, Marcondes S.PLoS One. 2015 Sep 16;10(9):e0137901. doi: 10.1371/journal.pone.0137901.
Pharmacological evaluation and preparation of nonsteroidal anti-inflammatory drugs containing an N-acy hydrazone subunit. de Melo TR , Chelucci RC, Pires ME, Dutra LA, Barbieri KP, Bosquesi PL, Trossini GH, Chung MC, dos Santos JL. Int J Mol Sci. 2014 Apr 4;15(4):5821-37. doi: 10.3390/ijms15045821.
Antiplatelet and antithrombotic activities of non-steroidal anti-inflammatory drugs containing an N-acyl hydrazone subunit. Chelucci RC, Dutra LA, Lopes-Pires ME, de Melo TR, Bosquesi PL, Chung MC, Dos Santos JL. Molecules. 2014 Feb 17;19(2):2089-99. doi: 10.3390/molecules19022089
Platelet hyperaggregability in high-fat fed rats: a role for intraplatelet reactive-oxygen species production. Monteiro PF, Morganti RP, Delbin MA, Calixto MC, Lopes-Pires ME, Marcondes S, Zanesco A, Antunes E. Cardiovasc Diabetol. 2012 Jan 16;11:5. doi: 10.1186/1475-2840-11-5.
Lipopolysaccharide treatment reduces rat platelet aggregation independent of intracellular reactive-oxygen species generation. Lopes-Pires ME, Casarin AL, Pereira-Cunha FG, Lorand-Metze I, Antunes E, Marcondes S. Platelets. 2012;23(3):195-201. doi: 10.3109/09537104.2011.603065.
Reactive oxygen and nitrogen species modulate the ex vivo effects of LPS on platelet adhesion to fibrinogen. Casarin AL, Lopes-Pires ME, Morganti RP, Antunes E, Marcondes S. Life Sci. 2011 Nov 21;89(21-22):773-8. doi: 10.1016/j.lfs.2011.09.004.
Research journey
Dr Lopes Pires is a cardiovascular pharmacologist who took part of Prof Jane Mitchell's and Dr Nicholas Kirkby's group at Vascular Biology section of the National Heart & Lung Institute. Her position was funded by British Heart Foundation Programme Grant. She worked with in vivo and ex vivo models of cardiovascular disease, seeking to understand the function of COX2 in the protection of cardiovascular system.
Dr Lopes Pires graduated in Biochemistry Pharmacy at UNESP (State University Julio de Mesquita Filho)- Brazil. In 2013, Dr Lopes Pires completed her PhD in Pharmacology at UNICAMP (State University of Campinas)- Brazil with Prof Sisi Marcondes, studying platelet reactivity and reactive oxygen species in sepsis condition (animal model). During this time, she did her doctoral internship at Université Jean Monnet- GIMAP- Pathophysiology and Prevention of infectious diseases- Santa Etienne-France, under supervision of Dr Fabrice Cognasse. She completed her first post-doctoral training under the guidance of Prof Jon Gibbins, at Reading University, where she worked with lipopolysaccharide effects in human platelet function. Before joining Imperial College, she worked at Anglia Ruskin University under the supervision of Dr Nick Pugh, completing a post-doctoral study about the function of zinc in human platelet reactivity.
Selected Publications
Clotting dysfunction in sepsis: a role for ROS and potential for therapeutic intervention. Lopes-Pires ME, Frade-Guanaes JO, Quinlan GJ. Antioxidants. 2022. Jan. doi: 10.3390/antiox11010088.
Endothelial cyclooxygenase-1 paradoxically drives local vasoconstriction and atherogenesis despite underpinning prostacyclin generation. Mitchell JA, Shala F, Pires MEL, Loy RY, Ravendren A, Benson J, Urquhart P, Nicolaou A, Herschman HR, Kirkby NS.Sci Adv. 2021 Mar 19;7(12):eabf6054. doi: 10.1126/sciadv.abf6054
Cyclooxygenases and the cardiovascular system Mitchell JA, Kirkby NS, Ahmetaj-Shala B, Armstrong PC, Crescente M, Ferreira P, Lopes Pires ME, Vaja R, Warner TD. Pharmacol Ther. 2021 Jan;217:107624. doi: 10.1016/j.pharmthera.2020.107624
Mitchell JA, Kirkby NS, Ahmetaj-Shala B, Armstrong PC, Crescente M, Ferreira P, Lopes Pires ME, Vaja R, Warner TD. Cyclooxygenases and the cardiovascular system. Pharmacol Ther. 2021 Jan;217:107624. doi: 10.1016/j.pharmthera.2020.107624
Agonist-Evoked Increases in Intra-Platelet Zinc Couple to Functional Responses. Ahmed NS, Lopes Pires ME, Taylor KA, Pugh N. Thrombosis and Haemost. 2019 Jan;119(1):128-139. doi: 10.1055/s-0038-1676589.
Lopes-Pires ME, Ahmed NS, Vara D, Gibbins JM, Pula G, Pugh N. Zinc regulates reactive oxygen species generation in platelets. Platelets. 2021 Apr 3;32(3):368-377. doi: 10.1080/09537104.2020.1742311
Signaling pathways involved in p47phox-dependent reactive-1 oxygen species in platelets of endotoxemic rats. Lopes Pires ME, Antunes AC, Antunes E, Garraud O, Cognasse F, Anhe GF, Marcondes S. Basic and Clinical Pharmacology and Toxicology. 2018 Oct 14. doi: 10.1111/bcpt.13148.
Tumor necrosis factor alpha has a crucial role on increased reactive oxygen species production in platelets of mice injected with lipopolysaccharide. Antunes AC, Bonfitto PH, Solon C, Lopes Pires ME, Anhe GF, Antunes E, Marcondes S. Platelets. 2018. (approved; waiting journal publication).
Stapled peptides as a new technology to investigate protein-protein interactions in human platelets. Jessica iegre, Niaz S Ahmed, Josephine S Gaynord, Yuteng Wu, Kara M Herlihy, Yaw Sing Tan, Maria E Lopes-Pires, Rupam Jha, Yu Heng Lau, Hannah Sore, Chandra Verma, Daniel H O'Donovan, Nicholas Pugh and David R Spring. Chemical Science. 2018 Apr 25;9(20):4638-4643. doi: 10.1039/C8SC00284C.
Sepsis: the involvement of platelets and the current treatments. Antunes AC, Guanaes JFO, Lopes Pires ME. Current Molecular Pharmacology. 2018 11(4):261-269. doi: 10.2174/187446721166618061912453
Platelet activity is negatively modulated by tumor necrosis factor alpha through reductions of cytosolic calcium levels and integrin alphaIIbbeta3 phosphorylation. Bonfitto PHL, Naime ACA, Lopes-Pires ME, Goulart G, Mendes-Silverio CB, Bueno PI, Castilho RF, Antunes E, Marcondes S. Thromb Res. 2018 Dec;172:44-5. doi: 10.1016/j.thromres.2018.10.008
Lipopolysaccharide potentiates platelet responses via toll-like receptor 4-stimulated Akt-Erk-PLA2 signalling. Lopes Pires ME, Clarke SR, Marcondes S, Gibbins JM. PLoS One. 2017 Nov 14;12(11):e0186981. doi: 10.1371/journal.pone.0186981.
Synthesis, antiplatelet and antithrombotic activities of resveratrol derivatives with NO-donor properties. Dutra LA, Guanaes JFO, Johmann N, Lopes Pires ME, Chin CM, Marcondes S, Dos Santos JL. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2450-2453. doi: 10.1016/j.bmcl.2017.04.007.
Cross-talking between lymphocytes and platelets and its regulation by nitric oxide and peroxynitrite in physiological condition and endotoxemia. Nádia J. Almeida Cardelli, M. Elisa Lopes-Pires, Pedro H. L. Bonfitto, Heloisa H. Ferreira, Edson Antunes, Sisi Marcondes. Life Sci. 2016 Dec 22. pii: S0024-3205(16)30708-1. doi: 10.1016/j.lfs.2016.12.013.
PKC and AKT Modulate cGMP/PKG Signaling Pathway on Platelet Aggregation in Experimental Sepsis. Lopes-Pires ME, Naime AC, Almeida Cardelli NJ, Anjos DJ, Antunes E, Marcondes S.PLoS One. 2015 Sep 16;10(9):e0137901. doi: 10.1371/journal.pone.0137901.
Pharmacological evaluation and preparation of nonsteroidal anti-inflammatory drugs containing an N-acy hydrazone subunit. de Melo TR , Chelucci RC, Pires ME, Dutra LA, Barbieri KP, Bosquesi PL, Trossini GH, Chung MC, dos Santos JL. Int J Mol Sci. 2014 Apr 4;15(4):5821-37. doi: 10.3390/ijms15045821.
Antiplatelet and antithrombotic activities of non-steroidal anti-inflammatory drugs containing an N-acyl hydrazone subunit. Chelucci RC, Dutra LA, Lopes-Pires ME, de Melo TR, Bosquesi PL, Chung MC, Dos Santos JL. Molecules. 2014 Feb 17;19(2):2089-99. doi: 10.3390/molecules19022089
Platelet hyperaggregability in high-fat fed rats: a role for intraplatelet reactive-oxygen species production. Monteiro PF, Morganti RP, Delbin MA, Calixto MC, Lopes-Pires ME, Marcondes S, Zanesco A, Antunes E. Cardiovasc Diabetol. 2012 Jan 16;11:5. doi: 10.1186/1475-2840-11-5.
Lipopolysaccharide treatment reduces rat platelet aggregation independent of intracellular reactive-oxygen species generation. Lopes-Pires ME, Casarin AL, Pereira-Cunha FG, Lorand-Metze I, Antunes E, Marcondes S. Platelets. 2012;23(3):195-201. doi: 10.3109/09537104.2011.603065.
Reactive oxygen and nitrogen species modulate the ex vivo effects of LPS on platelet adhesion to fibrinogen. Casarin AL, Lopes-Pires ME, Morganti RP, Antunes E, Marcondes S. Life Sci. 2011 Nov 21;89(21-22):773-8. doi: 10.1016/j.lfs.2011.09.004.
FACULTY
- Faculty of Medicine
POSITION NAME
- Teaching Fellow in Biomedical Science (Non-Clinica