DrMarco Briones Orta

PUBLICATIONS
Lepore A, Choy P, Lee N, Carella M, Favicchio R, Briones-Orta MA, Glaser S, Alpini G, D'Santos C, Papakyriakou A, Tooze R, Syn WK, Georgios G, Bubici C, Papa S. 2021. Direct phosphorylation and stabilization of PIN1 by JNK promotes tumorigenesis. Hepatology. doi: 10.1002/hep.31983. PMID: 34048060

Mehta KJ, Coombes JD, Briones-Orta M, Manka PP, Williams R, Patel VB, Syn WK.Iron Enhances Hepatic Fibrogenesis and Activates Transforming Growth Factor-β Signaling in Murine Hepatic Stellate Cells. Am J Med Sci. 2018 Feb;355(2):183-190. doi: 10.1016/j.amjms.2017.08.012. Epub 2017 Aug 23. PMID: 29406047

Briones-Orta MA, Avendaño-Vázquez SE, Ivette Aparicio-Bautista D, Coombes JD, Weber GF, Syn WK. Prediction of transcription factor bindings sites affected by SNPs located at the osteopontin promoter. Data Brief. 2017 Aug 2;14:538-542. doi: 10.1016/j.dib.2017.07.057. eCollection 2017 Oct. PMID: 28856185

Briones-Orta MA, Avendaño-Vázquez SE, Aparicio-Bautista DI, Coombes JD, Weber GF, Syn WK. Osteopontin splice variants and polymorphisms in cancer progression and prognosis. Biochim Biophys Acta Rev Cancer. 2017 Aug;1868(1):93-108.A. doi: 10.1016/j.bbcan.2017.02.005. Epub 2017 Feb 28. Review. PMID: 28254527

Coombes JD, Choi SS, Swiderska-Syn M, Manka P, Reid DT, Palma E, Briones-Orta MA, Xie G, Younis R, Kitamura N, Della Peruta M, Bitencourt S, Dollé L, Oo YH, Mi Z, Kuo PC, Williams R, Chokshi S, Canbay A, Claridge LC, Eksteen B, Diehl AM, Syn WK. Osteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis. Biochim Biophys Acta. 2016 Jan;1862(1):135-44. doi: 10.1016/j.bbadis.2015. 10.028. Epub 2015 Oct 31. PMID: 26529285

Vázquez-Victorio G, Caligaris C, Del Valle-Espinosa E, Sosa-Garrocho M, González-Arenas NR, Reyes-Cruz G, Briones-Orta MA, Macías-Silva M. Novel regulation of Ski protein stability and endosomal sorting by actin cytoskeleton dynamics in hepatocytes. J Biol Chem. 2015 Feb 13;290(7):4487-99. doi: 10.1074/jbc.M114.579532. Epub 2015 Jan 5. PMID: 25561741

Coombes JD, Swiderska-Syn M, Dollé L, Reid D, Eksteen B, Claridge L, Briones-Orta MA, Shetty S, Oo YH, Riva A, Chokshi S, Papa S, Mi Z, Kuo PC, Williams R, Canbay A, Adams DH, Diehl AM, van Grunsven LA, Choi SS, Syn WK. Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice. Gut. 2015 Jul;64(7):1120-31. doi: 10.1136/gutjnl-2013-306484. PMID: 24902765

Briones-Orta MA, Levy L, Madsen CD, Das D, Erker Y, Sahai E, Hill CS. Arkadia regulates tumor metastasis by modulation of the TGF-β pathway. Cancer Res. 2013 Mar 15;73(6):1800-10. doi: 10.1158/0008-5472.CAN-12-1916. Epub 2013 Mar 6. PMID: 23467611

Delgado-Coello B, Briones-Orta MA, Macías-Silva M, Mas-Oliva J. Cholesterol: recapitulation of its active role during liver regeneration. Liver Int. 2011 Oct;31(9):1271-84. doi: 10.1111/j.1478-3231.2011.02542.x. Epub 2011 May 3. Review. PMID: 21745289

Briones-Orta MA, Tecalco-Cruz AC, Sosa-Garrocho M, Caligaris C, Macías-Silva M. Inhibitory Smad7: emerging roles in health and disease. Curr Mol Pharmacol. 2011 Jun;4(2):141-53. Review. PMID: 21222648

Delgado-Coello B, Bravo-Martínez J, Sosa-Garrocho M, Briones-Orta MA, Macías-Silva M, Mas-Oliva J. Plasma membrane calcium ATPase isoform 3 expression in single cells isolated from rat liver. Mol Cell Biochem. 2010 Nov;344(1-2):117-24. doi: 10.1007/s11010-010-0535-1. Epub 2010 Jul 13. PMID: 20625796

Moreno-Alvarez P, Sosa-Garrocho M, Briones-Orta MA, González-Espinosa C, Medina-Tamayo J, Molina-Jijón E, Pedraza-Chaverri J, Macías-Silva M. Angiotensin II increases mRNA levels of all TGF-beta isoforms in quiescent and activated rat hepatic stellate cells. Cell Biol Int. 2010 Oct;34(10):969-78. doi: 10.1042/CBI20090074. PMID: 20557291

Briones-Orta MA, Sosa-Garrocho M, Moreno-Alvarez P, Fonseca-Sánchez MA, Macías-Silva M. SnoN co-repressor binds and represses smad7 gene promoter.Biochem Biophys Res Commun. 2006 Mar 17;341(3):889-94. Epub 2006 Jan 23. PMID: 16442497

Vázquez-Macías A, Ruíz-Mendoza AB, Fonseca-Sánchez MA, Briones-Orta MA, Macías-Silva M. Downregulation of Ski and SnoN co-repressors by anisomycin. FEBS Lett. 2005 Jul 4;579(17):3701-6. PMID: 15967445