DrLynne Sykes

Clinical Associate Professor in Obstetrics

Department of Metabolism, Digestion and Reproduction - Faculty of Medicine

  • Clinical Associate Professor in Obstetrics
    Department of Metabolism, Digestion and Reproduction - Faculty of Medicine
  • 020 7594 2186 (Work)
  • 3007, Institute of Reproductive and Developmental Biology, Hammersmith Campus, United Kingdom

RESEARCH

Student supervision:


BSc
2015 Boyce,E. The effects of therapeutic concentrations of Sulfasalazine in amniocytes and Proinflammatory Genes in Human Amnion Epithelial Cells

2017 Anucha,E. The potential role of viral priming in the placenta in bacterial induced preterm labour

2018 Thurairajah, S. Peripheral blood neutrophil function in women at high risk of preterm labour (BSc in Immunology)

2019 Budwig, L. Leukocytes as predictive markers of histological chorioamnionitis in women with preterm prelabour rupture of fetal membranes

2020 Hyde, A. Maternal ABO phenotype and the risk of preterm birth

2022 Pasint-Magyar, J. Maternal ABO phenotype and the risk of preterm birth in a large population study

2022 Green, A. Maternal ABO phenotype and the risk of PPROM in a large population study

 

2023 Soubelet, O. Optimisation of immune phenotyping for the BUMP feasibility study 

 

2023 Dos Santos, M. Long term Treatment outcomes for Large uterine Fibroids 

 

2023 McCutcheon M. Endometrial receptivity of Uterine Anomalies 

 

2024 Karas, K. Rate of complications following emergency cervical cerclage at Imperial College Healthcare NHS Trust 

 

2024 Body, L. Vaginal microbiota opsonisation status in pregnant women treated with a live biotherapeutic 

 

2024 Suresh, N. Exploring disparities in ethnicity and preterm birth and its influence on recruitment into preterm birth prevention studies 

 

2024 Naseem, A. Endometrial receptivity of uterine anomalies 

 

2025 Tan, J. Ultrasound indicated cervical cerclage: Exploring complications, pregnancy outcomes, vaginal microbial composition and immune response. 

 

2025 Chan, E. Impact of maternal vaginal microbiome composition on pregnancy and neonatal outcomes in preterm birth 

 

2026 Harris, T. History indicated cervical cerclage: Exploring rates of complications and efficacy in reduction of spontaneous preterm birth 

 

2026 Brown, C. Associations between the gut microbiome and pregnancy outcomes 

 

2026 Tie-Gill, A. Cervical length surveillance and the risk of spontaneous preterm birth in women who have a multi-fetal pregnancy 

 

2026 Sina-Tanda, M. The risk of iatrogenic preterm birth in women who have a multi-fetal pregnancy.

 

 

MSc

2010 Hunte, E. The role of CRTH2 in murine myometrial contractility

2011 Yap, XJ. Chemoattractant Receptor Homologous to the T helper 2 cell (CRTH2) expression and function in T helper cells in pregnancy

2013 Thomson, K. Investigation of Sulfasalazine Treatment in the Prevention of Preterm Labour – Effect on NF-κB Activity

2014 Begum, Z. The anti-inflammatory effects of 15dPGJ2 in human cultured amniocytes

2017 Rai, R. The role of TLR3 in viral priming of myocytes

2017 Bura, S. Recognition of the vaginal microbiome by the maternal immune response in pregnancy.

2018 Ahmed, S. The vaginal microbiota and the local and systemic immune response in term and preterm deliveries

2018 San Martin, C. The role of TLR3 in viral priming of PBMCs


2018 Alqurashi, M. Normal and low density granulocytes in pregnancy, Labour and women at high risk of preterm labour (MSc in Immunology)

2023 Sandhu, B. Investigation of the complement cascade in human amnion cells 

 

2024 Stone, K. Immune signature for women at risk of preterm birth during the COVID-19 pandemic 

 

2024 Oseitwum-Paris, D. Characterisation of peripheral and cervical neutrophil effector functions 

 

2024 De Leon, B. Investigating immune signatures following preterm prelabour rupture of membranes

 

2025 Malik, Z. Characterisation of factors affecting bacterial opsonisation 

 

2026 Butler, V. Anti-surface layer protein antibodies in women treated with a live biotherapeutic Lactobacillus crispatus (LACTIN-V). 

 

2026 Moore, H. Infectious diseases in pregnancy: Epidemiology, Immunity and Screening in Northwest London

 

MD

2026 Tom Sewell Reproductive outcomes and endometrial receptivity before and after surgical correction of uterine septae in patients with recurrent miscarriage 


PhD

2019 Begam,Z, The role of viral priming in bacterial induced preterm labour
2020 Chan,D, Microbial – Maternal Host Immune Interactions in Pregnancy Preterm labour
2022: Gimeno-Molina,B, The role of neutrophils in microbial driven preterm birth
2025: Mountain, K. Patient stratification and prediction of preterm labour in women with prior cervical treatment and women with a history of PTB

GRANTS

  • PROGRAMME GRANT
    The Imperial College March of Dimes European Prematurity Research Centre 2022-2023 (Year 5 of P76171, linked to WSCR_P76171)
    March of Dimes
    March of Dimes: The Imperial College March of Dimes European Prematurity Research Centre 2022-2023 (Year 5 of P76171, linked to WSCR_P76171) (2022-2023)
  • PROGRAMME GRANT
    The Imperial College March of Dimes European Prematurity Research Centre 2023-2024
    March of Dimes
    March of Dimes: The Imperial College March of Dimes European Prematurity Research Centre 2023-2024 (2023-2027)