DrLouise Fleming

Louise Fleming is a Professor of Practice in Paediatric Respiratory Medicine. She is a Consultant Respiratory Paediatrician at the Royal Brompton hospital, where she leads the Severe Asthma Service and at Imperial College Healthcare Trust, where she leads the Paediatric Respiratory and Sleep Service for West London Children's Healthcare

Dr Fleming is a member of the Global Initiative for Asthma (GINA) Science Committee, Secretary of the Paediatric Asthma and Allergy group of the European Respiratory Society (ERS) and Academic representative of the British Paediatric Respiratory Society (BPRS) Executive Committee. She is an Associate Editor (respiratory) for Archives of Disease in Childhood. She is a strong advocate for children with asthma and improving care to deliver better outcomes. In order to achieve this, she is a member of a number of networks including: NHSE Children and Young People Asthma Oversight Group (chair of the severe asthma workstream); London Asthma Leadership and Implementation Group (LALIG); London Paediatric Severe Asthma Group (Chair); and North West London Paediatric asthma network. She has previously served on the BTS Specialist Advisory Group for Severe Asthma, the RSM Paediatrics and Child Health Council (past president), the British Thoracic Society (BTS) Science Committee and the BTS/SIGN clinical guidelines group.

Her main research focus is on asthma and pre-school wheeze. She runs several applied clinical research studies and collaborates with colleagues in molecular biology and data science. Her key research themes are: novel approaches to treatment and assessment of treatment response; harnessing digital technologies to improve asthma management; child and family factors; charactering asthma and pre school wheeze. She is the Chief Investigator of an NIHR HTA funded study of anti-inflammatory relievers in children (aged 6 to 11 years) with asthma: CARE-UK. Other current work includes novel adherence monitoring devices; use of biologics in children (TREAT trial); digital innovations to predict asthma attacks (CHAMP study), understanding determinants of poor adherence in the individual and targeting interventions accordingly.

Clinically she looks after children with a wide range of respiratory problems. Interests include the systematic multi-disciplinary assessment of children with problematic severe asthma and dysfunctional breathing.

Louise completed her undergraduate degree in medicine at the University of Manchester before moving to London for postgraduate training in Paediatrics. This included an 18-month VSO/RCPCH Fellowship in The Gambia. She undertook postgraduate research at NHLI and the Royal Brompton Hospital, funded by the British Lung Foundation, under the supervision of Professor Andrew Bush and Dr Nicola Wilson. She carried out a randomised controlled trial investigating the use of inflammatory markers to guide management in children with severe asthma.