MsKarina Al-Dahleh

My research focuses on stress-induced changes in the epitranscriptomic landscape and their impact on post-transcriptional gene regulation. I design and conduct experiments including primary cell culture and RNA extraction, and leverage both long-read (PacBio) and short-read RNA sequencing datasets to characterize transcript diversity and expression dynamics.
Through integrative transcriptomic analysis, I aim to better understand how RNA-based regulatory mechanisms drive cellular adaptation and contribute to disease-relevant processes.

Additionally, I designed and executed high-throughput screening (>50K compounds) against target RNA-modification enzyme, utilizing fluorescence polarization and thermal shift assays to identify and prioritize hit compounds for downstream development.

I am broadly interested in RNA biology, stress-response pathways, and translational applications of transcriptomics.