RESEARCH

- Development of novel microbiome therapeutics (including synthetic consortia, microbially-produced metabolites, and microbially-produced enzymes) to prevent or restrict the intestinal colonisation with multidrug-resistant pathogens
- Investigating the mechanisms for the intestinal decolonisation of multidrug-resistant microorganisms (in particular direct mechanisms of colonisation resistance, including nutrient competition and metabolite inhibition)
- Investigating the use of faecal microbiota transplantation (FMT) for the intestinal decolonisation of multidrug-resistant microorganisms
- Impact of host diet on gut microbiota composition and functionality
- Artificial gut ("chemostat") models to culture the distal gut microbiota

GRANTS

  • GRANT
    SELECTED
    Selected
    Decoding inter-species PICI transfer to understand bacterial evolution and design next-generation antibacterial therapies
    Wellcome Trust1 Dec 2025 - 30 Nov 2033
    Wellcome Trust: Decoding inter-species PICI transfer to understand bacterial evolution and design next-generation antibacterial therapies (2025-2033)
  • STANDARD - RESPONSE
    SELECTED
    Selected
    Harnessing nutrient metabolism by the gut microbiota to restrict the intestinal colonisation with multidrug-resistant pathogens
    Wellcome Trust1 Jan 2024 - 31 Dec 2031
    Wellcome Trust: Harnessing nutrient metabolism by the gut microbiota to restrict the intestinal colonisation with multidrug-resistant pathogens (2024-2031)
  • STANDARD - RESPONSE
    SELECTED
    Selected
    Using nutrient competition and metabolite production by the gut microbiota to reduce the growth of carbapenem-resistant Enterobacteriaceae in the gut
    Medical Research Council (MRC)8 Aug 2022 - 7 Dec 2025
    MRC: Using nutrient competition and metabolite production by the gut microbiota to reduce the growth of carbapenem-resistant Enterobacteriaceae in the gut (2022-2025)
  • STANDARD - RESPONSE
    REducing Greenhouse gas emissions and ENgaging antibactErial Resistance in Anaerobic Treated Effluents (REGENERATE)
    Engineering & Physical Science Research Council (E1 Jun 2023 - 31 May 2026
    Engineering & Physical Science Research Council (E: REducing Greenhouse gas emissions and ENgaging antibactErial Resistance in Anaerobic Treated Effluents (REGENERATE) (2023-2026)