DrJames Price
Honorary Clinical Senior Lecturer
Department of Infectious Disease - Faculty of Medicine
- Honorary Clinical Senior LecturerDepartment of Infectious Disease - Faculty of Medicine
- Commonwealth Building, Hammersmith Campus, United Kingdom
RESEARCH
Selected Publications
Bak A, Mugglestone MA, Ratnaraja NV, Wilson JA, Rivett L, Stoneham SM, Bostock J, Moses SE, Price JR, Weinbren M, Loveday HP, Islam J, Wilson APR. SARS-CoV-2 routes of transmission and recommendations for preventing acquisition: joint British Infection Association (BIA), Healthcare Infection Society (HIS), Infection Prevention Society (IPS) and Royal College of Pathologists (RCPath) guidance J Hosp Infect. 2021 Aug;114:79-103. doi: 10.1016/j.jhin.2021.04.027.
Hartley A, El-Sayed A, Abbara A, Ghazy A, Davies F, Price JR, Punjabi P, Anderson J, Casula R, Naderi H, Asaria P, Sutaria N, Malik I, Pabari P, Rana BS. Impact of Restriction on Cardiac Imaging in Infective Endocarditis: A Multi-Disciplinary Team Approach to the Management of Infective Endocarditis during the COVID-19 Pandemic. Cardiology Research and Practice 2021 Jul 30;2021:5565200. doi: 10.1155/2021/5565200
Price JR, Yokoyama M, Cole K, Sweetman J, Behar L, Stoneham S, Cantillon D, Waddell SJ, Hyde J, Alam R, Crook D, Paul J, Llewelyn MJ. Undetected carriage explains apparent Staphylococcus aureus acquisition in a non-outbreak healthcare setting. Journal of Infection. 2021 Sep;83(3):332-338.
Abbas M, Zhu NJ, Mookerjee S, Bolt F, Otter JA, Holmes AH, Price JR. Hospital-onset COVID-19 infection surveillance systems: a systematic review. Journal of Hospital Infection. 2021 Sep;115:44-50. doi: 10.1016/j.jhin.2021.05.016.
Bak A, Islam J, Mugglestone, M, Ratnaraja N, Bostock J, Wilson J, Moses S, Price JR, Weinbren M, Loveday H, Rivett L, Stoneham S, Wilson P. Routes of transmission of beta-coronaviruses: joint British Infection Association (BIA), Healthcare Infection Society (HIS), Infection Prevention Society (IPS) and Royal College of Pathologists (RCPath) guidance. Journal of Hospital Infection. 2021 Apr 30;S0195-6701(21)00180-8. doi: 10.1016/j.jhin.2021.04.027.
Al-Hassan L*, Roemer-Mahler*, Price JR*, Islam H, El-Mahallawy H, Higgins PG, Hussein AFA, Roca, I, Newport M. The TACTIC Experience: Establishing an International, Multidisciplinary Network to Tackle Antimicrobial Resistance. Journal of Medical Microbiology. 2020. doi: 10.1099/jmm.0.001249
Abbas M, Holmes AH, Price JR. Correspondence: Surgical site infections following elective surgery. Lancet Infectious Diseases 2020; 20(8): 898-899
Price JR*, Mookerjee S*, Dyakova E, Myall A, Leung W, Weiße AY, Shersing Y, Brannigan ET, Galletly T, Muir D, Randell P, Davies F, Bolt F, Barahona M, Otter JA, Holmes AH. Development and delivery of a real-time hospital-onset COVID-19 surveillance system using network analysis Clinical Infectious Diseases 2020; doi: 10.1093/cid/ciaa892
Zhou J, Otter JA, Price JR, Cimpeanu C, Garcia DM, Kinross J, Boshier PR, Mason S, Bolt F, Holmes AH, Barclay WS. Investigating SARS-CoV-2 surface and air contamination in an acute healthcare setting during the peak of the COVID-19 pandemic in London. Clinical Infectious Diseases2020; doi: 10.1093/cid/ciaa905
Tacconelli E, Mazzaferri F, de Smet AM, Bragantini D, Eggimann P, Huttner B, Kuijper EJ, Lucet J-C, Mutter NT, Souli M, Sanguinetti M, Schwaber MJ, Torre-Cisneros J, Price JR, Rodríguez-Baño J. ESCMID-EUCIC clinical guidelines on decolonisation of carriers by multidrug-resistant Gram-negative bacteria. Clinical Microbiology and Infection 2019; doi: 10.1016/j.cmi.2019.01.005. PMID: 30708122
Young B, Wu C-H, Gordon NC, Cole K, Price JR, Liu E, Sheppard A, Perera S, Charlesworth J, Golubchik T, Iqbal Z, Bowden R, Massey RC, Paul J, Crook DW, Peto TEA, Walker AS, Llewelyn MJ, Wyllie DH, Wilson DJ. Severe infections emerge from the microbiome by adaptive evolution. eLifeSciences. 2017
Price JR, Crook DW, Walker AS, Peto TEA, Llewelyn MJ, Paul J. Transmission of Staphylococcus aureus in Critical care – Author’s reply. Lancet ID. 2017;17(6) : 580-1
Gordon NC, Pichon B; Golubchik T, Wilson DJ, Paul J, Blanc DS, Cole K, Collins J, Cortes N, Cubbon M, Gould FK, Jenks P, Llewelyn MJ, Nash JQ, Orendi J, Paranthaman K, Price J, Senn L, Thomas HL, Wyllie S, Crook DW, Peto TEA, Walker AS, Kearns AM. Whole genome sequencing reveals the contribution of long-term carriers in Staphylococcus aureus outbreak investigation. J Clin Microbiol 2017 ; pii: JCM.00363-17. doi: 10.1128/JCM.00363-17
Ledda A, Price JR, Cole K, Llewelyn MJ, Kearns AM, Crook DW, Paul J, Didelot X. Re-emergence of methicillin susceptibility in a resistant lineage of Staphylococcus aureus. J Antimicrobial Chemotherapy (2017) dkw570
Price JR, Cole K, Bexley A, Kostiou V, Eyre DW, Golubchik T, Wilson DJ, Crook DW, Walker AS, Peto TEA, Llewelyn MJ, Paul J. Transmission of Staphylococcus aureus between healthcare workers, the environment and patients in an intensive care unit: a whole-genome sequencing based longitudinal cohort study. Lancet ID. 2016;S1473-3099(16):30413-3
Fitzpatrick JM, Biswas JS, Edgeworth JD, Islam J, Jenkins N, Judge R, Lavery AJ, Melzer M, Morris-Jones S, Nsutebu EF, Peters J, Pillay DG, Pink F, Price JR, Scarborough M, Thwaites GE, Tiley R, Walker AS, Llewelyn MJ; United Kingdom Clinical Infection Research Group. Gram-negative bacteraemia: a multi-centre prosprective evaluation of empiric antibiotic therapy and outcome in English acute hospitals. Clinical Microbiology and Infection. 2016;22(3):244-51
Price JR. Using art to improve public knowledge of MRSA. The Bulletin of the Royal College of Pathologists. 2015;171:163
Price JR, Golubchik T, Wilson DJ, Crook DW, Walker AS, Peto TE, Paul J, Llewelyn MJ. Reply to Mills and Linkin. Clinical Infectious Diseases 2014; 59(5):752-3. doi: 10.1093/cid/ciu370
Gordon NC, Price JR, Cole K, Everitt R, Morgan M, Finney J, Kearns AM, Pichon B, Young B, Wilson DJ, Llewelyn MJ, Paul J, Peto TE, Crook DW, Walker AS, Golubchik T. Prediction of Staphylococcus aureus antimicrobial resistance from whole genome sequencing. Journal of Clinical Microbiology. 2014; 52(4): 1182-1191
Miller R, Price JR, Batty E, Didelot X, Wyllie D, Golubchik T, Crook DW, Paul J, Peto TEA, Wilson DJ, Cule M, Ip C, Day NPJ, Moore CE, Bowden R, Llewelyn MJ Healthcare-associated outbreak of meticillin-resistant Staphylococcus aureus bacteraemia: role of a cryptic variant of an epidemic clone. Journal of Hospital Infection 2014; 86(2): 83-9.
Price JR, Golubchik T, Cole K, Wilson DJ, Crook DW, Thwaites GE, Bowden R, Walker AS, Peto TE, Paul J, Llewelyn MJ. Whole-genome sequencing shows that patient-to-patient transmission rarely accounts for acquisition of Staphylococcus aureus in an intensive care unit. Clinical Infectious Diseases. 2014;58(5):609-18
Price JR, Gordon NC, Crook DW, Llewelyn MJ, Paul J. (2012) The usefulness of whole genome sequencing in Staphylococcus aureus infection. Clinical Microbiology and Infection 2013;19(9):784-9
Price JR, Didelot X, Crook DW, Llewelyn MJ, Paul J. Whole genome sequencing in the prevention and control of Staphylococcus aureus infection. Journal of Hospital Infection 2013;83(1):14-21
Bailey SL, Price J, Llewelyn M. Fluke Infertility; the late cost of a quick swim. Journal of Travel Medicine 2011;18(1):61-62
Price J, Baker G, Heath I, Walker-Bone K, Cubbon M, Curtis S, Enright M, Lindsay J, Paul J, and Llewelyn M. Clinical and microbiological determinants of outcome in Staphylococcus aureus bacteraemia. International Journal of Microbiology Volume 2010; (2010): Article ID 654858
Price J, Cheek E, Lippett S, Cubbon M, Gerding DN, Sambol SP, Citron DM, Llewelyn M. Impact of an intervention to control Clostridium difficile infection on hospital- and community-onset disease ; an interupted time series analysis. Clinical Microbiology and Infection 2010;16(8):1297-302
Llewelyn M, Price J, Lippett S, Portsmouth J, Cubbon M. Combating healthcare associated infections; more evidence might help. British Medical Journal 2009;338:b1441
Price J, Atkinson S, Llewelyn M, Paul J. Paradoxical Relationship between Staphylococcus aureus bacteraemia clinical outcome and Vancomycin minimum inhibitory concentration. Clinical Infectious Diseases 2009;48(7):997-8
Collaborative Publications
Kemp SA, Collier DA, Datir RP, Ferreira IATM, Gayed S, Jahun A, Hosmillo M, Rees-Spear C, Mlcochova P, Lumb IU, Roberts DJ, Chandra A, Temperton N; CITIID-NIHR BioResource COVID-19 Collaboration; COVID-19 Genomics UK (COG-UK) Consortium, Sharrocks K, Blane E, Modis Y, Leigh KE, Briggs JAG, van Gils MJ, Smith KGC, Bradley JR, Smith C, Doffinger R, Ceron-Gutierrez L, Barcenas-Morales G, Pollock DD, Goldstein RA, Smielewska A, Skittrall JP, Gouliouris T, Goodfellow IG, Gkrania-Klotsas E, Illingworth CJR, McCoy LE, Gupta RK. SARS-CoV-2 evolution during treatment of chronic infection. Nature. 2021 Apr;592(7853):277-282. doi: 10.1038/s41586-021-03291-y.
Collier DA, De Marco A, Ferreira IATM, Meng B, Datir RP, Walls AC, Kemp SA, Bassi J, Pinto D, Silacci-Fregni C, Bianchi S, Tortorici MA, Bowen J, Culap K, Jaconi S, Cameroni E, Snell G, Pizzuto MS, Pellanda AF, Garzoni C, Riva A; CITIID-NIHR BioResource COVID-19 Collaboration, Elmer A, Kingston N, Graves B, McCoy LE, Smith KGC, Bradley JR, Temperton N, Ceron-Gutierrez L, Barcenas-Morales G; COVID-19 Genomics UK (COG-UK) Consortium, Harvey W, Virgin HW, Lanzavecchia A, Piccoli L, Doffinger R, Wills M, Veesler D, Corti D, Gupta RK. Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies. Nature. 2021 May;593(7857):136-141. doi: 10.1038/s41586-021-03412-7.
Meng B, Kemp SA, Papa G, Datir R, Ferreira IATM, Marelli S, Harvey WT, Lytras S, Mohamed A, Gallo G, Thakur N, Collier DA, Mlcochova P; COVID-19 Genomics UK (COG-UK) Consortium, Duncan LM, Carabelli AM, Kenyon JC, Lever AM, De Marco A, Saliba C, Culap K, Cameroni E, Matheson NJ, Piccoli L, Corti D, James LC, Robertson DL, Bailey D, Gupta RK. Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7. Cell Rep. 2021 Jun 29;35(13):109292. doi: 10.1016/j.celrep.2021.109292.
Graham MS, Sudre CH, May A, Antonelli M, Murray B, Varsavsky T, Kläser K, Canas LS, Molteni E, Modat M, Drew DA, Nguyen LH, Polidori L, Selvachandran S, Hu C, Capdevila J; COVID-19 Genomics UK (COG-UK) Consortium, Hammers A, Chan AT, Wolf J, Spector TD, Steves CJ, Ourselin S. Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study. Lancet Public Health . 2021 May;6(5):e335-e345. doi: 10.1016/S2468-2667(21)00055-4
Volz E, Mishra S, Chand M, Barrett JC, Johnson R, Geidelberg L, Hinsley WR, Laydon DJ, Dabrera G, O'Toole Á, Amato R, Ragonnet-Cronin M, Harrison I, Jackson B, Ariani CV, Boyd O, Loman NJ, McCrone JT, Gonçalves S, Jorgensen D, Myers R, Hill V, Jackson DK, Gaythorpe K, Groves N, Sillitoe J, Kwiatkowski DP; COVID-19 Genomics UK (COG-UK) consortium, Flaxman S, Ratmann O, Bhatt S, Hopkins S, Gandy A, Rambaut A, Ferguson NM. Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England. Nature. 2021 May;593(7858):266-269. doi: 10.1038/s41586-021-03470-x.
Volz E, Hill V, McCrone JT, Price A, Jorgensen D, O'Toole Á, Southgate J, Johnson R, Jackson B, Nascimento FF, Rey SM, Nicholls SM, Colquhoun RM, da Silva Filipe A, Shepherd J, Pascall DJ, Shah R, Jesudason N, Li K, Jarrett R, Pacchiarini N, Bull M, Geidelberg L, Siveroni I; COG-UK Consortium, Goodfellow I, Loman NJ, Pybus OG, Robertson DL, Thomson EC, Rambaut A, Connor TR. Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity. Cell . 2021 Jan 7;184(1):64-75.e11. doi: 10.1016/j.cell.2020.11.020.
Alm E, Broberg EK, Connor T, Hodcroft E, Komissarov AB, Maurer-Stroh S, Melidou A, Neher R, O’Toole A, Pereyaslov D, The WHO European Region sequencing laboratories and GISAID EpiCoV group. Geographic and temporal distribution of SARS-CoV-2 clades in the WHO European Region from January to June 2020. Eurosurveillance 2020; 25(32):2001410. doi: 10.2807/1560-7917.ES.2020.25.32.2001410.
Kuehl R, Morata L, Boeing C, Subirana I, Seifert H, Rieg S, Kern WV, Kim HB, Kim ES, Liao CH, Tilley R, Lopez-Cortés LE, Llewelyn MJ, Fowler VG, Thwaites G, Cisneros JM, Scarborough M, Nsutebu E, Gurgui Ferrer M, Pérez JL, Barlow G, Hopkins S, Ternavasio-de la Vega HG, Török ME, Wilson P, Kaasch AJ, Soriano A; International Staphylococcus aureus collaboration study group and the ESCMID Study Group for Bloodstream Infections, Endocarditis and Sepsis. Defining persistent Staphylococcus aureus bacteraemia: secondary analysis of a prospective cohort study. 2020 Dec;20(12):1409-1417. doi: 10.1016/S1473-3099(20)30447-3.
Nambiar K, Seifert H, Rieg S, Kern WV, Scarborough M, Gordon NC, Kim HB, Song KH, Tilley R, Gott H, Liao CH, Edgeworth J, Nsutebu E, López-Cortés LE, Morata L, Walker AS, Thwaites G, Llewelyn MJ, Kaasch AJ; International Staphylococcus aureus collaboration (ISAC) study group and the ESCMID Study Group for Bloodstream Infections and Sepsis (ESGBIS). Survival following Staphylococcus aureus bloodstream infection: A prospective multinational cohort study assessing the impact of place of care. J Infect. 2018 Dec;77(6):516-525. doi: 10.1016/j.jinf.2018.08.015.
Thwaites GE, Scarborough M, Szubert A, Nsutebu E, Tilley R, Greig J, Wyllie SA, Wilson P, Auckland C, Cairns J, Ward D, Lal P, Guleri A, Jenkins N, Sutton J, Wiselka M, Armando G-R, Graham C, Chadwick PR, Barlow G, Gordon NC, Young B, Meisner S, McWhinney P, Price DA, Harvey D, Nayar D, Jeyaratnam D, Planche T, Minton J, Hudson F, Hopkins S, Williams J, Török ME, Llewelyn MJ, Edgeworth JD, Walker AS, on behalf of the United Kingdom Clinical Infection Research Group (United Kingdom Clinical Infection Research Group (UKCIRG)). Adjunctive Rifampicin for Staphylococcus aureus bacteaemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet. 2017 http://dx.doi.org/10.1016/S0140-6736(17)32456-X
Kaasch AJ, Barlow G, Edgeworth JD, Fowler VG Jr, Hellmich M, Hopkins S, Kern WV, Llewelyn MJ, Rieg S, Rodriguez-Baño J, Scarborough M, Seifert H, Soriano A, Tilley R, Tőrők ME, Weiß V, Wilson AP, Thwaites GE; ISAC, INSTINCT, SABG, UKCIRG, and Colleagues. Staphylococcus aureus bloodstream infection: a pooled analysis of five prospective, observational studies. J Infect. 2014 Mar;68(3):242-51.
Hope R, Blackburn RM, Verlander NQ, Johnson AP, Kearns A, Hill R, Hopkins S, Sheridan E, Livermore DM on behalf of Vancomycin Outcome Study Group and the UK Clinical Infection Research Group (UKCIRG). Vancomycin MIC as a predictor of outcome in MRSA bacteraemia in the UK context. Journal of Antimicrobial Chemotherapy 2013; 68(11): 2641-7
Thwaites G, Auckland C, Barlow G, Cunningham R, Davies G, Edgeworth J, Greig J, Hopkins S, Jeyaratnam D, Jenkins N, Llewelyn M, Meisner S, Nsutebu E, Planche T, Read RC, Scarborough M, Soares M, Tilley R, Török ME, Williams J, Wilson P, Wyllie S, Walker AS; United Kingdom Clinical Infection Research Group (UKCIRG). Adjunctive rifampicin to reduce early mortality from Staphylococcus aureus bacteraemia (ARREST): study protocol for a randomised controlled trial. Trials. 2012;13:241.
Thwaites G, United Kingdom Clinical Infection Research Group (UKCIRG). Clinical management of Staphylococcus aureus bacteraemia. Lancet Infectious Diseases 2011;11(3):208-22
Thwaites G, United Kingdom Clinical Infection Research Group (UKCIRG). The management of Staphylococcus aureus bacteraemia in the United Kingdom and Vietnam: a multi-centre evaluation. PLoS One 2010;5(12):e14170
Prizes and Awards
European Society for Clinical Microbiology and Infectious Diseases (ESCMID) Young Investigators Award for Research in Infectious Diseases and Microbiology (2018)
Royal College of Pathologists Research Medal in Medical Microbiology (2017)
Barnett Christie Lecture. Awarded by the British Infection Association (2016) Presented at Healthcare Infection Society (HIS)-Federation of Infection Societies (FIS) Annual Conference, Edinburgh, UK (2016)
Research areas
Utility of biotechnologies to address healthcare-associated infections and antimicrobial resistance
Translation of microbial whole-genome sequencing into clinical practice
Modernising infection prevention for global healthcare
Antimicrobial resistance as an evolving global health threat
Healthcare-associated Staphylococcus aureus: carriage, transmission and invasive disease
Roles
Director of Infection Prevention and Control, Imperial College Healthcare NHS Trust, London
Consultant in Infectious Diseases and Microbiology, Imperial College Healthcare NHS Trust, London
National Quality Assurance Advisory Panel (NQAAP) in Medical Microbiology
NHS England Hospital-Onset COVID-19 infection working group
COVID Genomics UK (COG-UK) Hospital-onset COVID-19 infection group
Chair of the Professional Development Committee, Healthcare Infection Society
Chair of the Federation of Infection Societies Scientific Programme Committee 2022
Healthcare Infection Society Guideline Committee (2019 to date)
Bak A, Mugglestone MA, Ratnaraja NV, Wilson JA, Rivett L, Stoneham SM, Bostock J, Moses SE, Price JR, Weinbren M, Loveday HP, Islam J, Wilson APR. SARS-CoV-2 routes of transmission and recommendations for preventing acquisition: joint British Infection Association (BIA), Healthcare Infection Society (HIS), Infection Prevention Society (IPS) and Royal College of Pathologists (RCPath) guidance J Hosp Infect. 2021 Aug;114:79-103. doi: 10.1016/j.jhin.2021.04.027.
Hartley A, El-Sayed A, Abbara A, Ghazy A, Davies F, Price JR, Punjabi P, Anderson J, Casula R, Naderi H, Asaria P, Sutaria N, Malik I, Pabari P, Rana BS. Impact of Restriction on Cardiac Imaging in Infective Endocarditis: A Multi-Disciplinary Team Approach to the Management of Infective Endocarditis during the COVID-19 Pandemic. Cardiology Research and Practice 2021 Jul 30;2021:5565200. doi: 10.1155/2021/5565200
Price JR, Yokoyama M, Cole K, Sweetman J, Behar L, Stoneham S, Cantillon D, Waddell SJ, Hyde J, Alam R, Crook D, Paul J, Llewelyn MJ. Undetected carriage explains apparent Staphylococcus aureus acquisition in a non-outbreak healthcare setting. Journal of Infection. 2021 Sep;83(3):332-338.
Abbas M, Zhu NJ, Mookerjee S, Bolt F, Otter JA, Holmes AH, Price JR. Hospital-onset COVID-19 infection surveillance systems: a systematic review. Journal of Hospital Infection. 2021 Sep;115:44-50. doi: 10.1016/j.jhin.2021.05.016.
Bak A, Islam J, Mugglestone, M, Ratnaraja N, Bostock J, Wilson J, Moses S, Price JR, Weinbren M, Loveday H, Rivett L, Stoneham S, Wilson P. Routes of transmission of beta-coronaviruses: joint British Infection Association (BIA), Healthcare Infection Society (HIS), Infection Prevention Society (IPS) and Royal College of Pathologists (RCPath) guidance. Journal of Hospital Infection. 2021 Apr 30;S0195-6701(21)00180-8. doi: 10.1016/j.jhin.2021.04.027.
Al-Hassan L*, Roemer-Mahler*, Price JR*, Islam H, El-Mahallawy H, Higgins PG, Hussein AFA, Roca, I, Newport M. The TACTIC Experience: Establishing an International, Multidisciplinary Network to Tackle Antimicrobial Resistance. Journal of Medical Microbiology. 2020. doi: 10.1099/jmm.0.001249
Abbas M, Holmes AH, Price JR. Correspondence: Surgical site infections following elective surgery. Lancet Infectious Diseases 2020; 20(8): 898-899
Price JR*, Mookerjee S*, Dyakova E, Myall A, Leung W, Weiße AY, Shersing Y, Brannigan ET, Galletly T, Muir D, Randell P, Davies F, Bolt F, Barahona M, Otter JA, Holmes AH. Development and delivery of a real-time hospital-onset COVID-19 surveillance system using network analysis Clinical Infectious Diseases 2020; doi: 10.1093/cid/ciaa892
Zhou J, Otter JA, Price JR, Cimpeanu C, Garcia DM, Kinross J, Boshier PR, Mason S, Bolt F, Holmes AH, Barclay WS. Investigating SARS-CoV-2 surface and air contamination in an acute healthcare setting during the peak of the COVID-19 pandemic in London. Clinical Infectious Diseases2020; doi: 10.1093/cid/ciaa905
Tacconelli E, Mazzaferri F, de Smet AM, Bragantini D, Eggimann P, Huttner B, Kuijper EJ, Lucet J-C, Mutter NT, Souli M, Sanguinetti M, Schwaber MJ, Torre-Cisneros J, Price JR, Rodríguez-Baño J. ESCMID-EUCIC clinical guidelines on decolonisation of carriers by multidrug-resistant Gram-negative bacteria. Clinical Microbiology and Infection 2019; doi: 10.1016/j.cmi.2019.01.005. PMID: 30708122
Young B, Wu C-H, Gordon NC, Cole K, Price JR, Liu E, Sheppard A, Perera S, Charlesworth J, Golubchik T, Iqbal Z, Bowden R, Massey RC, Paul J, Crook DW, Peto TEA, Walker AS, Llewelyn MJ, Wyllie DH, Wilson DJ. Severe infections emerge from the microbiome by adaptive evolution. eLifeSciences. 2017
Price JR, Crook DW, Walker AS, Peto TEA, Llewelyn MJ, Paul J. Transmission of Staphylococcus aureus in Critical care – Author’s reply. Lancet ID. 2017;17(6) : 580-1
Gordon NC, Pichon B; Golubchik T, Wilson DJ, Paul J, Blanc DS, Cole K, Collins J, Cortes N, Cubbon M, Gould FK, Jenks P, Llewelyn MJ, Nash JQ, Orendi J, Paranthaman K, Price J, Senn L, Thomas HL, Wyllie S, Crook DW, Peto TEA, Walker AS, Kearns AM. Whole genome sequencing reveals the contribution of long-term carriers in Staphylococcus aureus outbreak investigation. J Clin Microbiol 2017 ; pii: JCM.00363-17. doi: 10.1128/JCM.00363-17
Ledda A, Price JR, Cole K, Llewelyn MJ, Kearns AM, Crook DW, Paul J, Didelot X. Re-emergence of methicillin susceptibility in a resistant lineage of Staphylococcus aureus. J Antimicrobial Chemotherapy (2017) dkw570
Price JR, Cole K, Bexley A, Kostiou V, Eyre DW, Golubchik T, Wilson DJ, Crook DW, Walker AS, Peto TEA, Llewelyn MJ, Paul J. Transmission of Staphylococcus aureus between healthcare workers, the environment and patients in an intensive care unit: a whole-genome sequencing based longitudinal cohort study. Lancet ID. 2016;S1473-3099(16):30413-3
Fitzpatrick JM, Biswas JS, Edgeworth JD, Islam J, Jenkins N, Judge R, Lavery AJ, Melzer M, Morris-Jones S, Nsutebu EF, Peters J, Pillay DG, Pink F, Price JR, Scarborough M, Thwaites GE, Tiley R, Walker AS, Llewelyn MJ; United Kingdom Clinical Infection Research Group. Gram-negative bacteraemia: a multi-centre prosprective evaluation of empiric antibiotic therapy and outcome in English acute hospitals. Clinical Microbiology and Infection. 2016;22(3):244-51
Price JR. Using art to improve public knowledge of MRSA. The Bulletin of the Royal College of Pathologists. 2015;171:163
Price JR, Golubchik T, Wilson DJ, Crook DW, Walker AS, Peto TE, Paul J, Llewelyn MJ. Reply to Mills and Linkin. Clinical Infectious Diseases 2014; 59(5):752-3. doi: 10.1093/cid/ciu370
Gordon NC, Price JR, Cole K, Everitt R, Morgan M, Finney J, Kearns AM, Pichon B, Young B, Wilson DJ, Llewelyn MJ, Paul J, Peto TE, Crook DW, Walker AS, Golubchik T. Prediction of Staphylococcus aureus antimicrobial resistance from whole genome sequencing. Journal of Clinical Microbiology. 2014; 52(4): 1182-1191
Miller R, Price JR, Batty E, Didelot X, Wyllie D, Golubchik T, Crook DW, Paul J, Peto TEA, Wilson DJ, Cule M, Ip C, Day NPJ, Moore CE, Bowden R, Llewelyn MJ Healthcare-associated outbreak of meticillin-resistant Staphylococcus aureus bacteraemia: role of a cryptic variant of an epidemic clone. Journal of Hospital Infection 2014; 86(2): 83-9.
Price JR, Golubchik T, Cole K, Wilson DJ, Crook DW, Thwaites GE, Bowden R, Walker AS, Peto TE, Paul J, Llewelyn MJ. Whole-genome sequencing shows that patient-to-patient transmission rarely accounts for acquisition of Staphylococcus aureus in an intensive care unit. Clinical Infectious Diseases. 2014;58(5):609-18
Price JR, Gordon NC, Crook DW, Llewelyn MJ, Paul J. (2012) The usefulness of whole genome sequencing in Staphylococcus aureus infection. Clinical Microbiology and Infection 2013;19(9):784-9
Price JR, Didelot X, Crook DW, Llewelyn MJ, Paul J. Whole genome sequencing in the prevention and control of Staphylococcus aureus infection. Journal of Hospital Infection 2013;83(1):14-21
Bailey SL, Price J, Llewelyn M. Fluke Infertility; the late cost of a quick swim. Journal of Travel Medicine 2011;18(1):61-62
Price J, Baker G, Heath I, Walker-Bone K, Cubbon M, Curtis S, Enright M, Lindsay J, Paul J, and Llewelyn M. Clinical and microbiological determinants of outcome in Staphylococcus aureus bacteraemia. International Journal of Microbiology Volume 2010; (2010): Article ID 654858
Price J, Cheek E, Lippett S, Cubbon M, Gerding DN, Sambol SP, Citron DM, Llewelyn M. Impact of an intervention to control Clostridium difficile infection on hospital- and community-onset disease ; an interupted time series analysis. Clinical Microbiology and Infection 2010;16(8):1297-302
Llewelyn M, Price J, Lippett S, Portsmouth J, Cubbon M. Combating healthcare associated infections; more evidence might help. British Medical Journal 2009;338:b1441
Price J, Atkinson S, Llewelyn M, Paul J. Paradoxical Relationship between Staphylococcus aureus bacteraemia clinical outcome and Vancomycin minimum inhibitory concentration. Clinical Infectious Diseases 2009;48(7):997-8
Collaborative Publications
Kemp SA, Collier DA, Datir RP, Ferreira IATM, Gayed S, Jahun A, Hosmillo M, Rees-Spear C, Mlcochova P, Lumb IU, Roberts DJ, Chandra A, Temperton N; CITIID-NIHR BioResource COVID-19 Collaboration; COVID-19 Genomics UK (COG-UK) Consortium, Sharrocks K, Blane E, Modis Y, Leigh KE, Briggs JAG, van Gils MJ, Smith KGC, Bradley JR, Smith C, Doffinger R, Ceron-Gutierrez L, Barcenas-Morales G, Pollock DD, Goldstein RA, Smielewska A, Skittrall JP, Gouliouris T, Goodfellow IG, Gkrania-Klotsas E, Illingworth CJR, McCoy LE, Gupta RK. SARS-CoV-2 evolution during treatment of chronic infection. Nature. 2021 Apr;592(7853):277-282. doi: 10.1038/s41586-021-03291-y.
Collier DA, De Marco A, Ferreira IATM, Meng B, Datir RP, Walls AC, Kemp SA, Bassi J, Pinto D, Silacci-Fregni C, Bianchi S, Tortorici MA, Bowen J, Culap K, Jaconi S, Cameroni E, Snell G, Pizzuto MS, Pellanda AF, Garzoni C, Riva A; CITIID-NIHR BioResource COVID-19 Collaboration, Elmer A, Kingston N, Graves B, McCoy LE, Smith KGC, Bradley JR, Temperton N, Ceron-Gutierrez L, Barcenas-Morales G; COVID-19 Genomics UK (COG-UK) Consortium, Harvey W, Virgin HW, Lanzavecchia A, Piccoli L, Doffinger R, Wills M, Veesler D, Corti D, Gupta RK. Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies. Nature. 2021 May;593(7857):136-141. doi: 10.1038/s41586-021-03412-7.
Meng B, Kemp SA, Papa G, Datir R, Ferreira IATM, Marelli S, Harvey WT, Lytras S, Mohamed A, Gallo G, Thakur N, Collier DA, Mlcochova P; COVID-19 Genomics UK (COG-UK) Consortium, Duncan LM, Carabelli AM, Kenyon JC, Lever AM, De Marco A, Saliba C, Culap K, Cameroni E, Matheson NJ, Piccoli L, Corti D, James LC, Robertson DL, Bailey D, Gupta RK. Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7. Cell Rep. 2021 Jun 29;35(13):109292. doi: 10.1016/j.celrep.2021.109292.
Graham MS, Sudre CH, May A, Antonelli M, Murray B, Varsavsky T, Kläser K, Canas LS, Molteni E, Modat M, Drew DA, Nguyen LH, Polidori L, Selvachandran S, Hu C, Capdevila J; COVID-19 Genomics UK (COG-UK) Consortium, Hammers A, Chan AT, Wolf J, Spector TD, Steves CJ, Ourselin S. Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study. Lancet Public Health . 2021 May;6(5):e335-e345. doi: 10.1016/S2468-2667(21)00055-4
Volz E, Mishra S, Chand M, Barrett JC, Johnson R, Geidelberg L, Hinsley WR, Laydon DJ, Dabrera G, O'Toole Á, Amato R, Ragonnet-Cronin M, Harrison I, Jackson B, Ariani CV, Boyd O, Loman NJ, McCrone JT, Gonçalves S, Jorgensen D, Myers R, Hill V, Jackson DK, Gaythorpe K, Groves N, Sillitoe J, Kwiatkowski DP; COVID-19 Genomics UK (COG-UK) consortium, Flaxman S, Ratmann O, Bhatt S, Hopkins S, Gandy A, Rambaut A, Ferguson NM. Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England. Nature. 2021 May;593(7858):266-269. doi: 10.1038/s41586-021-03470-x.
Volz E, Hill V, McCrone JT, Price A, Jorgensen D, O'Toole Á, Southgate J, Johnson R, Jackson B, Nascimento FF, Rey SM, Nicholls SM, Colquhoun RM, da Silva Filipe A, Shepherd J, Pascall DJ, Shah R, Jesudason N, Li K, Jarrett R, Pacchiarini N, Bull M, Geidelberg L, Siveroni I; COG-UK Consortium, Goodfellow I, Loman NJ, Pybus OG, Robertson DL, Thomson EC, Rambaut A, Connor TR. Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity. Cell . 2021 Jan 7;184(1):64-75.e11. doi: 10.1016/j.cell.2020.11.020.
Alm E, Broberg EK, Connor T, Hodcroft E, Komissarov AB, Maurer-Stroh S, Melidou A, Neher R, O’Toole A, Pereyaslov D, The WHO European Region sequencing laboratories and GISAID EpiCoV group. Geographic and temporal distribution of SARS-CoV-2 clades in the WHO European Region from January to June 2020. Eurosurveillance 2020; 25(32):2001410. doi: 10.2807/1560-7917.ES.2020.25.32.2001410.
Kuehl R, Morata L, Boeing C, Subirana I, Seifert H, Rieg S, Kern WV, Kim HB, Kim ES, Liao CH, Tilley R, Lopez-Cortés LE, Llewelyn MJ, Fowler VG, Thwaites G, Cisneros JM, Scarborough M, Nsutebu E, Gurgui Ferrer M, Pérez JL, Barlow G, Hopkins S, Ternavasio-de la Vega HG, Török ME, Wilson P, Kaasch AJ, Soriano A; International Staphylococcus aureus collaboration study group and the ESCMID Study Group for Bloodstream Infections, Endocarditis and Sepsis. Defining persistent Staphylococcus aureus bacteraemia: secondary analysis of a prospective cohort study. 2020 Dec;20(12):1409-1417. doi: 10.1016/S1473-3099(20)30447-3.
Nambiar K, Seifert H, Rieg S, Kern WV, Scarborough M, Gordon NC, Kim HB, Song KH, Tilley R, Gott H, Liao CH, Edgeworth J, Nsutebu E, López-Cortés LE, Morata L, Walker AS, Thwaites G, Llewelyn MJ, Kaasch AJ; International Staphylococcus aureus collaboration (ISAC) study group and the ESCMID Study Group for Bloodstream Infections and Sepsis (ESGBIS). Survival following Staphylococcus aureus bloodstream infection: A prospective multinational cohort study assessing the impact of place of care. J Infect. 2018 Dec;77(6):516-525. doi: 10.1016/j.jinf.2018.08.015.
Thwaites GE, Scarborough M, Szubert A, Nsutebu E, Tilley R, Greig J, Wyllie SA, Wilson P, Auckland C, Cairns J, Ward D, Lal P, Guleri A, Jenkins N, Sutton J, Wiselka M, Armando G-R, Graham C, Chadwick PR, Barlow G, Gordon NC, Young B, Meisner S, McWhinney P, Price DA, Harvey D, Nayar D, Jeyaratnam D, Planche T, Minton J, Hudson F, Hopkins S, Williams J, Török ME, Llewelyn MJ, Edgeworth JD, Walker AS, on behalf of the United Kingdom Clinical Infection Research Group (United Kingdom Clinical Infection Research Group (UKCIRG)). Adjunctive Rifampicin for Staphylococcus aureus bacteaemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet. 2017 http://dx.doi.org/10.1016/S0140-6736(17)32456-X
Kaasch AJ, Barlow G, Edgeworth JD, Fowler VG Jr, Hellmich M, Hopkins S, Kern WV, Llewelyn MJ, Rieg S, Rodriguez-Baño J, Scarborough M, Seifert H, Soriano A, Tilley R, Tőrők ME, Weiß V, Wilson AP, Thwaites GE; ISAC, INSTINCT, SABG, UKCIRG, and Colleagues. Staphylococcus aureus bloodstream infection: a pooled analysis of five prospective, observational studies. J Infect. 2014 Mar;68(3):242-51.
Hope R, Blackburn RM, Verlander NQ, Johnson AP, Kearns A, Hill R, Hopkins S, Sheridan E, Livermore DM on behalf of Vancomycin Outcome Study Group and the UK Clinical Infection Research Group (UKCIRG). Vancomycin MIC as a predictor of outcome in MRSA bacteraemia in the UK context. Journal of Antimicrobial Chemotherapy 2013; 68(11): 2641-7
Thwaites G, Auckland C, Barlow G, Cunningham R, Davies G, Edgeworth J, Greig J, Hopkins S, Jeyaratnam D, Jenkins N, Llewelyn M, Meisner S, Nsutebu E, Planche T, Read RC, Scarborough M, Soares M, Tilley R, Török ME, Williams J, Wilson P, Wyllie S, Walker AS; United Kingdom Clinical Infection Research Group (UKCIRG). Adjunctive rifampicin to reduce early mortality from Staphylococcus aureus bacteraemia (ARREST): study protocol for a randomised controlled trial. Trials. 2012;13:241.
Thwaites G, United Kingdom Clinical Infection Research Group (UKCIRG). Clinical management of Staphylococcus aureus bacteraemia. Lancet Infectious Diseases 2011;11(3):208-22
Thwaites G, United Kingdom Clinical Infection Research Group (UKCIRG). The management of Staphylococcus aureus bacteraemia in the United Kingdom and Vietnam: a multi-centre evaluation. PLoS One 2010;5(12):e14170
Prizes and Awards
European Society for Clinical Microbiology and Infectious Diseases (ESCMID) Young Investigators Award for Research in Infectious Diseases and Microbiology (2018)
Royal College of Pathologists Research Medal in Medical Microbiology (2017)
Barnett Christie Lecture. Awarded by the British Infection Association (2016) Presented at Healthcare Infection Society (HIS)-Federation of Infection Societies (FIS) Annual Conference, Edinburgh, UK (2016)
Research areas
Utility of biotechnologies to address healthcare-associated infections and antimicrobial resistance
Translation of microbial whole-genome sequencing into clinical practice
Modernising infection prevention for global healthcare
Antimicrobial resistance as an evolving global health threat
Healthcare-associated Staphylococcus aureus: carriage, transmission and invasive disease
Roles
Director of Infection Prevention and Control, Imperial College Healthcare NHS Trust, London
Consultant in Infectious Diseases and Microbiology, Imperial College Healthcare NHS Trust, London
National Quality Assurance Advisory Panel (NQAAP) in Medical Microbiology
NHS England Hospital-Onset COVID-19 infection working group
COVID Genomics UK (COG-UK) Hospital-onset COVID-19 infection group
Chair of the Professional Development Committee, Healthcare Infection Society
Chair of the Federation of Infection Societies Scientific Programme Committee 2022
Healthcare Infection Society Guideline Committee (2019 to date)