ProfessorDarrel Francis

Professor of Cardiology

National Heart & Lung Institute - Faculty of Medicine

  • Professor of Cardiology
    National Heart & Lung Institute - Faculty of Medicine
  • 020 7594 5735 (Work)
  • Block B Hammersmith Hospital, Hammersmith Campus, United Kingdom

RESEARCH

Research Team
Our unit bridges many aspects of cardiology including coronary physiology, quantitative imaging, devices/electrophyiology, heart failure, rational prevention and clinical effectiveness.The key Research Leaders in the group are Dr Justin Davies, Dr Zachary Whinnett and Dr Charlotte Manisty. We could not exist without our close clinical and research integration with Electrophysiology (Prof Nick Peters, Dr P Kanagaratnam), Imaging (Prof J Mayet) and enthusiastic support of the Coronary Intervention consultants.

Our researchers are a mix of cardiologists, engineers and physiologists, working on rational steps to improve methods for diagnosis and treatment for real challenges in cardiology. Our approaches are many, including designing, building and testing new equipment and software, developing new analytical techniques, re-examining existing methods, and conducting trials.

We do not shy away from controversial areas, since we believe that it is those questions that gain the most from careful, accurate illumination.

Mechanical dyssynchrony controversy

Bone-marrow stem cell controversy - journal responses (appendices 6 to 9) - press coverage: 1 2

Perioperative beta blockade controversy - press coverage: 1 2

We have an active interest in erroneous research findings which we believe can arise in many ways, mostly inadvertantly through inadequate planning of research, the perceived pressure to publish at all costs, or the common incorrect belief that positive results are more worthwhile than neutral ones. We seek, develop and share more reliable methods for research and clinical practice.

GRANTS

  • STANDARD - CALL
    Unifying the assessment of left ventricular function across imaging modalities using artificial intelligence openly developed by a UK-wide collaboration of experts
    British Heart Foundation18 Dec 2025 - 17 Dec 2028
    BHF: Unifying the assessment of left ventricular function across imaging modalities using artificial intelligence openly developed by a UK-wide collaboration of experts (2025-2028)
  • GRANT
    Improving beta-blocker use in heart failure: A randomised n-of-1 trial to identify nocebo effects and inform patients' decision making
    British Heart Foundation1 Dec 2024 - 30 Nov 2027
    BHF: Improving beta-blocker use in heart failure: A randomised n-of-1 trial to identify nocebo effects and inform patients' decision making (2024-2027)
  • STANDARD - CALL
    BRC Cardiovascular Theme Budget Allocation (2022-2027)
    Imperial College Healthcare NHS Trust- BRC Funding1 Dec 2022 - 31 Mar 2028
    Imperial College Healthcare NHS Trust- BRC Funding: BRC Cardiovascular Theme Budget Allocation (2022-2027) (2022-2028)
  • STANDARD - RESPONSE
    Unity AI Research Programme
    Imperial College Healthcare NHS Trust1 Aug 2021 - 31 Dec 2022
    Imperial College Healthcare NHS Trust: Unity AI Research Programme (2021-2022)
  • GRANT
    The Impact of the Coronary Sinus Reducer on Myocardial Perfusion, Coronary Flow and Symptoms in Patients with Refractory Angina: A Randomised Placebo Controlled Trial
    Medical Research Council (MRC)6 Jan 2021 - 5 Jan 2024
    MRC: The Impact of the Coronary Sinus Reducer on Myocardial Perfusion, Coronary Flow and Symptoms in Patients with Refractory Angina: A Randomised Placebo Controlled Trial (2021-2024)
  • GRANT
    Tensor-Mapping to Resolve the Achilles - Heels of Echocardiographic Strain Imaging
    British Heart Foundation1 Jan 2020 - 31 Dec 2022
    BHF: Tensor-Mapping to Resolve the Achilles - Heels of Echocardiographic Strain Imaging (2020-2022)
  • GRANT
    Is there a difference between clinical angina and experimentally inducible angina? A placebo-controlled experiment on symptoms in stable coronary artery disease
    Medical Research Council (MRC)2 Oct 2019 - 1 Oct 2022
    MRC: Is there a difference between clinical angina and experimentally inducible angina? A placebo-controlled experiment on symptoms in stable coronary artery disease (2019-2022)
  • GRANT
    Effect of antianginals on common tests for cardiac ischaemia
    National Institute for Health Research1 Oct 2019 - 30 Sep 2022
    NIHR: Effect of antianginals on common tests for cardiac ischaemia (2019-2022)
  • GRANT
    Machine learning to support general physicians using hand-held echocardiography in acutely unwell patients: Leveraging Imperial's large-scale outcome-linked, echocardiography dataset
    Imperial College Healthcare NHS Trust: Research Capability Funding (RCF)1 Sep 2019 - 31 Mar 2021
    Imperial College Healthcare NHS Trust: Research Capability Funding (RCF): Machine learning to support general physicians using hand-held echocardiography in acutely unwell patients: Leveraging Imperial's large-scale outcome-linked, echocardiography dataset (2019-2021)
  • GRANT
    Effects of PCSK9 inhibition on coronary microvascular function
    Amgen Limited30 Jan 2019 - 29 Jan 2022
    Amgen Limited: Effects of PCSK9 inhibition on coronary microvascular function (2019-2022)
  • GRANT
    Exploring the pressure-flow velocity characteristics of coronary stenoses pre and post Transcatheter Aortic Valve Insertion (TAVI).
    Imperial Health Charity1 Apr 2018 - 31 Mar 2019
    Imperial Health Charity: Exploring the pressure-flow velocity characteristics of coronary stenoses pre and post Transcatheter Aortic Valve Insertion (TAVI). (2018-2019)
  • GRANT
    ORBITA 2 - BRC
    Imperial College Healthcare NHS Trust- BRC Funding1 Apr 2018 - 30 Nov 2022
    Imperial College Healthcare NHS Trust- BRC Funding: ORBITA 2 - BRC (2018-2022)
  • GRANT
    The National Health Informatics Collaboration Cardiovascular (NHIC-CV) Project / UK-BIOmedical research centre Evaluation of Troponin: national Health Informatics Collaboration (UK-BIOETHIC)
    Imperial College Healthcare NHS Trust- BRC Funding1 Apr 2018 - 31 Mar 2019
    Imperial College Healthcare NHS Trust- BRC Funding: The National Health Informatics Collaboration Cardiovascular (NHIC-CV) Project / UK-BIOmedical research centre Evaluation of Troponin: national Health Informatics Collaboration (UK-BIOETHIC) (2018-2019)
  • GRANT
    The Imperial Immunity, Inflammation, Infection and Informatics (4i) Clinician Scientist Programme
    Wellcome Trust1 Jul 2017 - 13 May 2025
    Wellcome Trust: The Imperial Immunity, Inflammation, Infection and Informatics (4i) Clinician Scientist Programme (2017-2025)
  • GRANT
    Exploring the pressure-flow velocity characteristics of coronary stenoses pre and post Transcatheter Aortic Valve Implantation (TAVI)
    National Institute for Health Research1 Apr 2017 - 31 Mar 2018
    NIHR: Exploring the pressure-flow velocity characteristics of coronary stenoses pre and post Transcatheter Aortic Valve Implantation (TAVI) (2017-2018)
  • GRANT
    First-in-human blinded placebo-controlled randomised trial of coronary stenting for relief of chronic stable angina ("ORBITA")
    Imperial College Healthcare NHS Trust- BRC Funding1 Apr 2017 - 31 Mar 2018
    Imperial College Healthcare NHS Trust- BRC Funding: First-in-human blinded placebo-controlled randomised trial of coronary stenting for relief of chronic stable angina ("ORBITA") (2017-2018)
  • GRANT
    Investigation of the physiological mechanisms through which ventricular tachycardia impairs cardiac function and exploration of potential clinical applicable therapy to improve cardiac output during VT.
    British Heart Foundation1 Apr 2016 - 31 Mar 2019
    BHF: Investigation of the physiological mechanisms through which ventricular tachycardia impairs cardiac function and exploration of potential clinical applicable therapy to improve cardiac output during VT. (2016-2019)
  • GRANT
    AV optimisation delivered with direct His bundle pacing, in patients with heart failure, long PR and normal QRS duration: randomised multi-centre clinical outcome study.
    British Heart Foundation1 Jan 2016 - 31 Jan 2021
    BHF: AV optimisation delivered with direct His bundle pacing, in patients with heart failure, long PR and normal QRS duration: randomised multi-centre clinical outcome study. (2016-2021)
  • GRANT
    Statin side effect or not? A patient-empowering within-patient randomized controlled trial and development of a practical technology to support 21st century primary
    British Heart Foundation1 Dec 2015 - 30 Mar 2021
    BHF: Statin side effect or not? A patient-empowering within-patient randomized controlled trial and development of a practical technology to support 21st century primary (2015-2021)
  • GRANT
    Funding - Dan Keene
    Imperial Health Charity7 Oct 2015 - 6 Oct 2016
    Imperial Health Charity: Funding - Dan Keene (2015-2016)
  • GRANT
    Quantitative test of the resynchronization hypothesis: relative contribution of AV delay and resynchronization, with development of open-access cross-modality tools for haemodynamic optimization and response quantification
    British Heart Foundation1 Jan 2015 - 31 Dec 2017
    BHF: Quantitative test of the resynchronization hypothesis: relative contribution of AV delay and resynchronization, with development of open-access cross-modality tools for haemodynamic optimization and response quantification (2015-2017)
  • GRANT
    The development and implementation of automated methods for the reproducible assessment of aortic stenosis and mitral regurgitation
    British Heart Foundation1 Oct 2014 - 30 Sep 2017
    BHF: The development and implementation of automated methods for the reproducible assessment of aortic stenosis and mitral regurgitation (2014-2017)
  • GRANT
    Exploring the pressure-flow velocity characteristics of coronary stenoses pre and post Transcutaneous Aortic Valve Insertion (TAVI)
    The Academy of Medical Sciences1 Jul 2014 - 30 Jun 2016
    The Academy of Medical Sciences: Exploring the pressure-flow velocity characteristics of coronary stenoses pre and post Transcutaneous Aortic Valve Insertion (TAVI) (2014-2016)
  • GRANT
    Serial DSPECT mIBG for Assessment of the Mechanism of Resistance to Renal Denervation Therapy
    Guys & St Thomas NHS Foundation Trust1 Apr 2014 - 31 Mar 2016
    Guys & St Thomas NHS Foundation Trust: Serial DSPECT mIBG for Assessment of the Mechanism of Resistance to Renal Denervation Therapy (2014-2016)
  • GRANT
    Serial DSPECT mIBG in Assessment of the Mechanism of Resistance to Renal Denervation Therapy part 2
    Imperial College Healthcare NHS Trust- BRC Funding1 Apr 2014 - 31 Mar 2016
    Imperial College Healthcare NHS Trust- BRC Funding: Serial DSPECT mIBG in Assessment of the Mechanism of Resistance to Renal Denervation Therapy part 2 (2014-2016)