ProfessorDarrel Francis
Professor of Cardiology
National Heart & Lung Institute - Faculty of Medicine
Orcid identifier0000-0002-3410-0814 (opens in a new tab)
- Professor of CardiologyNational Heart & Lung Institute - Faculty of Medicine
- 020 7594 5735 (Work)
- Block B Hammersmith Hospital, Hammersmith Campus, United Kingdom
RESEARCH
Research Team
Our unit bridges many aspects of cardiology including coronary physiology, quantitative imaging, devices/electrophyiology, heart failure, rational prevention and clinical effectiveness.The key Research Leaders in the group are Dr Justin Davies, Dr Zachary Whinnett and Dr Charlotte Manisty. We could not exist without our close clinical and research integration with Electrophysiology (Prof Nick Peters, Dr P Kanagaratnam), Imaging (Prof J Mayet) and enthusiastic support of the Coronary Intervention consultants.
Our researchers are a mix of cardiologists, engineers and physiologists, working on rational steps to improve methods for diagnosis and treatment for real challenges in cardiology. Our approaches are many, including designing, building and testing new equipment and software, developing new analytical techniques, re-examining existing methods, and conducting trials.
We do not shy away from controversial areas, since we believe that it is those questions that gain the most from careful, accurate illumination.
Mechanical dyssynchrony controversy
Bone-marrow stem cell controversy - journal responses (appendices 6 to 9) - press coverage: 1 2
Perioperative beta blockade controversy - press coverage: 1 2
We have an active interest in erroneous research findings which we believe can arise in many ways, mostly inadvertantly through inadequate planning of research, the perceived pressure to publish at all costs, or the common incorrect belief that positive results are more worthwhile than neutral ones. We seek, develop and share more reliable methods for research and clinical practice.
Our unit bridges many aspects of cardiology including coronary physiology, quantitative imaging, devices/electrophyiology, heart failure, rational prevention and clinical effectiveness.The key Research Leaders in the group are Dr Justin Davies, Dr Zachary Whinnett and Dr Charlotte Manisty. We could not exist without our close clinical and research integration with Electrophysiology (Prof Nick Peters, Dr P Kanagaratnam), Imaging (Prof J Mayet) and enthusiastic support of the Coronary Intervention consultants.
Our researchers are a mix of cardiologists, engineers and physiologists, working on rational steps to improve methods for diagnosis and treatment for real challenges in cardiology. Our approaches are many, including designing, building and testing new equipment and software, developing new analytical techniques, re-examining existing methods, and conducting trials.
We do not shy away from controversial areas, since we believe that it is those questions that gain the most from careful, accurate illumination.
Mechanical dyssynchrony controversy
Bone-marrow stem cell controversy - journal responses (appendices 6 to 9) - press coverage: 1 2
Perioperative beta blockade controversy - press coverage: 1 2
We have an active interest in erroneous research findings which we believe can arise in many ways, mostly inadvertantly through inadequate planning of research, the perceived pressure to publish at all costs, or the common incorrect belief that positive results are more worthwhile than neutral ones. We seek, develop and share more reliable methods for research and clinical practice.
GRANTS
- STANDARD - CALLUnifying the assessment of left ventricular function across imaging modalities using artificial intelligence openly developed by a UK-wide collaboration of expertsBritish Heart Foundation18 Dec 2025 - 17 Dec 2028
- GRANTImproving beta-blocker use in heart failure: A randomised n-of-1 trial to identify nocebo effects and inform patients' decision makingBritish Heart Foundation1 Dec 2024 - 30 Nov 2027
- STANDARD - CALLBRC Cardiovascular Theme Budget Allocation (2022-2027)Imperial College Healthcare NHS Trust- BRC Funding1 Dec 2022 - 31 Mar 2028
- STANDARD - RESPONSEUnity AI Research ProgrammeImperial College Healthcare NHS Trust1 Aug 2021 - 31 Dec 2022
- GRANTThe Impact of the Coronary Sinus Reducer on Myocardial Perfusion, Coronary Flow and Symptoms in Patients with Refractory Angina: A Randomised Placebo Controlled TrialMedical Research Council (MRC)6 Jan 2021 - 5 Jan 2024
- GRANTTensor-Mapping to Resolve the Achilles - Heels of Echocardiographic Strain ImagingBritish Heart Foundation1 Jan 2020 - 31 Dec 2022
- GRANTIs there a difference between clinical angina and experimentally inducible angina? A placebo-controlled experiment on symptoms in stable coronary artery diseaseMedical Research Council (MRC)2 Oct 2019 - 1 Oct 2022
- GRANTEffect of antianginals on common tests for cardiac ischaemiaNational Institute for Health Research1 Oct 2019 - 30 Sep 2022
- GRANTMachine learning to support general physicians using hand-held echocardiography in acutely unwell patients: Leveraging Imperial's large-scale outcome-linked, echocardiography datasetImperial College Healthcare NHS Trust: Research Capability Funding (RCF)1 Sep 2019 - 31 Mar 2021
- GRANTEffects of PCSK9 inhibition on coronary microvascular functionAmgen Limited30 Jan 2019 - 29 Jan 2022
- GRANTExploring the pressure-flow velocity characteristics of coronary stenoses pre and post Transcatheter Aortic Valve Insertion (TAVI).Imperial Health Charity1 Apr 2018 - 31 Mar 2019
- GRANTORBITA 2 - BRCImperial College Healthcare NHS Trust- BRC Funding1 Apr 2018 - 30 Nov 2022
- GRANTThe National Health Informatics Collaboration Cardiovascular (NHIC-CV) Project / UK-BIOmedical research centre Evaluation of Troponin: national Health Informatics Collaboration (UK-BIOETHIC)Imperial College Healthcare NHS Trust- BRC Funding1 Apr 2018 - 31 Mar 2019
- GRANTThe Imperial Immunity, Inflammation, Infection and Informatics (4i) Clinician Scientist ProgrammeWellcome Trust1 Jul 2017 - 13 May 2025
- GRANTExploring the pressure-flow velocity characteristics of coronary stenoses pre and post Transcatheter Aortic Valve Implantation (TAVI)National Institute for Health Research1 Apr 2017 - 31 Mar 2018
- GRANTFirst-in-human blinded placebo-controlled randomised trial of coronary stenting for relief of chronic stable angina ("ORBITA")Imperial College Healthcare NHS Trust- BRC Funding1 Apr 2017 - 31 Mar 2018
- GRANTInvestigation of the physiological mechanisms through which ventricular tachycardia impairs cardiac function and exploration of potential clinical applicable therapy to improve cardiac output during VT.British Heart Foundation1 Apr 2016 - 31 Mar 2019
- GRANTAV optimisation delivered with direct His bundle pacing, in patients with heart failure, long PR and normal QRS duration: randomised multi-centre clinical outcome study.British Heart Foundation1 Jan 2016 - 31 Jan 2021
- GRANTStatin side effect or not? A patient-empowering within-patient randomized controlled trial and development of a practical technology to support 21st century primaryBritish Heart Foundation1 Dec 2015 - 30 Mar 2021
- GRANTFunding - Dan KeeneImperial Health Charity7 Oct 2015 - 6 Oct 2016
- GRANTQuantitative test of the resynchronization hypothesis: relative contribution of AV delay and resynchronization, with development of open-access cross-modality tools for haemodynamic optimization and response quantificationBritish Heart Foundation1 Jan 2015 - 31 Dec 2017
- GRANTThe development and implementation of automated methods for the reproducible assessment of aortic stenosis and mitral regurgitationBritish Heart Foundation1 Oct 2014 - 30 Sep 2017
- GRANTExploring the pressure-flow velocity characteristics of coronary stenoses pre and post Transcutaneous Aortic Valve Insertion (TAVI)The Academy of Medical Sciences1 Jul 2014 - 30 Jun 2016
- GRANTSerial DSPECT mIBG for Assessment of the Mechanism of Resistance to Renal Denervation TherapyGuys & St Thomas NHS Foundation Trust1 Apr 2014 - 31 Mar 2016
- GRANTSerial DSPECT mIBG in Assessment of the Mechanism of Resistance to Renal Denervation Therapy part 2Imperial College Healthcare NHS Trust- BRC Funding1 Apr 2014 - 31 Mar 2016