Dr Claire Broderick is a post-CCT NIHR Clinical Lecturer in the Section of Adult Infectious Disease and a practising clinician in Infectious Diseases and Microbiology. Her research focuses on immune responses to infectious diseases and their interactions with coinfections, age, anti-microbial therapeutics and other factors, working towards improved diagnostic biomarkers, therapies and vaccines.

She undertook her medical training at the University of Cambridge and University College London followed by integrated clinical academic training in London. She completed a Wellcome 4i Imperial PhD fellowship in the Department of Infectious Disease, Imperial, in which she studied TB-influenza coinfection. Using a mycobacterial growth inhibition assay within an influenza human challenge study, she showed that systemic influenza infection inhibits whole blood control of mycobacteria. Whole blood RNA-sequencing, cytokine and cellular analyses revealed that influenza infection impairs key innate anti-mycobacterial immune responses. Her work suggests that influenza may be a risk factor for TB disease and influenza vaccination might offer protection against TB disease (Broderick et al, Nature Communications in press 2026).  

Claire has developed expertise in studying longitudinal transcriptomic responses to infections such as influenza, SARS-CoV-2 and TB. While an NIHR Academic Clinical Fellow at LSHTM, with funding from Rosetrees and BIA, she used the whole blood transcriptomic response to treatment to identify “responders” and “non-responders” amongst a group of TB-sensitised contacts taking preventive therapy (PT) for “latent” TB infection. She is interested in developing this experimental medicine approach further, aiming to discover new biomarkers for use in PT and TB vaccine clinical trials. Claire is also a member of the international DIAMONDS consortium, which aims to develop novel biomarkers to improve diagnosis and management of febrile patients.

Claire is presently leading a study, supported by an Academy of Medical Sciences starter grant, that is investigating the impact of ageing on immune responses to bacterial and viral infections, and on performance of traditional and novel infection biomarkers. She is working with the NIHR-supported bioresource BioAID.