ProfessorAnne Lingford-Hughes, PhD BMBCH FRCPsych

Professor Anne Lingford-Hughes FMedSci is Professor of Addiction Biology at Imperial College London. She is also a Consultant Psychiatrist with a particular interest in pharmacological treatments of alcohol and opiate addictions at Central North West London NHS Foundation Trust. Her research has focused on using neuroimaging and neuropharmacological challenges to characterize the neurobiology of addiction. She has used positron emission tomography (PET) and fMRI to characterize the dopamine (DRD2, DRD3), opioid (mu), GABA-benzodiazepine (a5 subtype), GABA-B, NK1 receptor systems in a range of substance addictions including alcoholism, cocaine and opiate dependence in the ICCAM protocol as well disordered gambling. More recently she has been exploring how to facilitate successful opiate detoxification in 2 projects: A:using neuroimaging of brain processes (eg mediating reward, cue reactivity) to assess the potential of NK1 antagonism to attenuate any dysregulation & B: a clinical trial to assess the potential of baclofen (GABA-B agonist) in reducing methadone doses during detox (the FORWARDS trial). The aim of her research programme is to better understand neurobiology underpinning these disorders to improve treatment.

Professor Anne Lingford-Hughes leads the MRC Addiction Research Clinical Training Programme (MARC) with Prof Colin Drummond, IOPPN, KCL and Prof Matt Hickman, University of Bristol. For events and opportunities associated with MARC see https://www.imperial.ac.uk/medicine/study/mrc-addiction-research-clinical-training/.

Professor Anne Lingford-Hughes is Chair, Addiction Healthcare Goals, Office for Life Sciences. https://www.gov.uk/government/publications/life-sciences-healthcare-goals/addiction-healthcare-goals.

Professor Anne Lingford-Hughes was elected as Fellow of Medical Academy of Sciences (2026) and recevied Lifetime Achievement award from British Association for Psychopharmacology (2026).

Prof Lingford-Hughes is past Hon. General Secretary of the British Association for Psychopharmacology. She co-developed and wrote their guidelines about the pharmacological management of substance misuse and addiction and comorbidity with psychiatric disorders. She has also contributed to NICE guidance regarding pharmacotherapy of opiate detoxification and NICE and PHE/OHID guidance about alcohol misuse and dependence. 

She was Professional Liaison Officer, British Neuroscience Association, and was Chair of the Academic Faculty of RCPsych.

She graduated in medicine from Oxford University, completed her PhD at Cambridge University, and trained in psychiatry at The Bethlem and Maudsley Hospitals and Institute of Psychiatry.

Professor Lingford-Hughes works as an Hon Consultant Psychiatrist in the Addictions Directorate, CNWL NHS Foundation Trust.