DrAlice Mitchell

Alice Mitchell, Ph.D., is a Postdoctoral Research Associate working with Prof. Catherine Williamson at the Institute of Reproductive Biology, Imperial College London. Her research focuses on the mechanisms underlying gestational diseases including intrahepatic cholestasis of pregnancy and gestational diabetes mellitus. She has been involved with setting up clinical trials for gestational diabetes, with focus on mechanistic sub-studies, and has helped to initiate and coordinate a novel cooling therapy study for children with metabolic dysfunction-associated steatotic liver disease.

Her work established the threshold concentration of serum bile acids for diagnosis of intrahepatic cholestasis of pregnancy which has been adopted into the UK Greentop Guidelines. Current projects are focused on the role of lipids and adipose tissue changes in pregnancy and metabolic changes that may impact itch and severity of cholestasis during pregnancy. Alongside her work in cholestasis, Alice is also investigating gut hormone responses of women with gestational diabetes treated with a potential therapeutic, ursodeoxycholic acid (GUARDS trial).