DrAran Singanayagam

KEY PUBLICATIONS

Katsoulis O, Toussaint M, Jackson MM......Singananayagam A* Neutrophil extracellular traps promote immunopathogenesis of virus-induced COPD exacerbations. Nature Communications 2024; 15: 5766. *Corresponding Author

Almond M, Farne H, K, Jackson MM.......Singanayagam A*. Obesity dysregulates the pulmonary antiviral immune response. Nature Communications 2023. 14: 6607. *Corresponding Author

George PM, Reed A, Desai S……Singanayagam A*. A persistent neutrophil-associated immune signature characterises post-COVID19 pulmonary sequelae. Science Translational Medicine 2022; 14: 671. *Corresponding Author

Singanayagam A*, Foottit J, Marcyzynski M et al. Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease. J Clin Invest 2022; 132: e120901. *Corresponding Author

Kamal F, Kumar S, Edwards MR……Singanayagam A*, Hanna GB*. Virus-induced volatile organic compounds are detectable in exhaled breath during pulmonary infection. Am J Respir Crit Care Med 2021 204:1075-1085. *Joint senior authors

Finney L, Glanville N……..Singanayagam A*. Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon. J Allerg Clin Immunol 2021; 147: 510-19. *Corresponding Author

Singanayagam A*, Glanville N, Cuthbertson L….Johnston SL. Inhaled corticosteroid suppression of cathelicidin drives dysbiosis and bacterial infection in chronic obstructive pulmonary disease. Science Translational Medicine 2019; 11 (507). *Corresponding Author

Singanayagam A, Glanville N, Girkin JG…….Johnston SL. Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations. Nature Communications 2018; 9: 2229.


PRINCIPAL INVESTIGATOR FUNDING
MRC Experimental Medicine grant. £1,906,212. 2024-2027.
MRC-CMM Co-infections grant. £45,000. 2022-2023.
Jameel Fund for Infectious Disease Research grant. £48,148. 2022-23.
Royal Society research grant. £20,000. 2022-2023.
MRC Clinician Scientist Fellowship. £1,123,600. 2020 - 2024.
British Medical Association James Trust grant for research into asthma. £64,641. 2020-2023.
NIHR Imperial BRC Respiratory Shadow Theme Call. £50,000. 2020 - 2021.
British Society of Antimicrobial Chemotherapy COVID-19 Grant. £25,000. 2020-2021.
Wellcome Trust Seed Award in Science. £50,000. 2019 - 2020.
Association of Physicians of GB & Ireland Young Investigator Award. £20,000. 2019 - 2020.
Wellcome Trust/Imperial College ISSF Springboard Fellowship. £114,876. 2019 - 2020.
British Medical Association HC Roscoe Grant. £50,000. 2015 - 2018.
British Lung Foundation Pump Priming Grant. £25,000. 2015 - 2016.
Wellcome Trust Clinical Research Training Fellowship. £248,724. 2011 - 2014.

CO-INVESTIGATOR FUNDING
Rosetrees Trust /Stoneygate Trust project grant. £89,992. 2022-2024 (PI: Dr Robert Snelgrove).
Sanofi Genzyme Type 2 innovation grant. £72,174. 2020 - 2021 (PI: Dr Robert Snelgrove).
HIC-VAC Pump Priming Grant. £71,803. 2021-2022 (PI: Dr Hugo Farne).

HONOURS AND PRIZES

ACS Infectious Diseases Young Investigator Prize 2025 

British Thoracic Society Mid Career Investigator Award 2024.

European Respiratory Journal top peer reviewer award 2020.
Worshipful Apothecaries' Society Prize for best research paper 2019.
European Respiratory Society best respiratory infection abstract 2016.
International Workshop for Lung Health. Rising Star Award 2016.
British Thoracic Society Early Career Investigator Award 2015.
European Respiratory Society COPD research abstract award 2012.

EDITORIAL RESPONSIBILITIES
BMJ Open Respir Res Associate Editor
Frontiers in Immunology, Guest Editor: "Role of lung and gut microbiota in the immune response against respiratory viral infections".
American Journal of Respiratory and Critical Care Medicine. Editorial Board Member
European Respiratory Journal. Editorial Board Member.