RESEARCH

Overview
Grant support from the following agencies:

EPSRC, BBSRC, MRC, DTI-Smart, Wellcome Trust, Leverhulme Trust, CRUK

Collaborative support from the following companies:

AstraZeneca, GlaxoSmithKline, Novartis, Roche, Sanofi-Aventis, Pfizer, Syngenta, Bayer Cropscience, GE Healthcare, Avecia

Total synthesis of bioactive natural products: anti-tumour Amaryllidaceae alkaloids, anti-HIV Celastraceae sesquiterpenoids and anti-asthma macrolides
Development of asymmetric nucleophilic organocatalysts for acylation of alcohols and amines
Development of organogermanium chemistry for use in novel parallel synthesis linkers
Novel methods for supported-synthesis of isotopically labeled compounds for e.g. Positron Emission Tomography (PET)
Development of antagonists to protein-protein interactions - IgE/high affinity receptor
The interactions of thiols with nitric oxide - S-nitrosothiol and sulfenic acid chemistry
Development of nuclear receptor protein regulators as potential anti-cancer therapeutic leads